2001
DOI: 10.1101/gad.894001
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“It Takes Two to Tango”: understanding how centrosome duplication is regulated throughout the cell cycle

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Cited by 245 publications
(199 citation statements)
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References 125 publications
(132 reference statements)
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“…Analysis of the subcellular localization of endogenous S5A protein revealed that, similar to ID1, a fraction of cellular S5A is localized at centrosomes. Similar centrosomal localization patterns have been reported for other components of the proteasome (Freed et al, 1999;Wigley et al, 1999;Fabunmi et al, 2000;Andersen et al, 2003), Localization of proteasome components at the centrosome might be crucial for centrosome duplication (reviewed in Hinchcliffe and Sluder, 2001). Supporting an important function of proteasome components during centrosome duplication are our findings that knockdown of S5A by shRNA caused an increase of cells with supernumerary centrioles (Figure 4).…”
Section: Discussionsupporting
confidence: 88%
“…Analysis of the subcellular localization of endogenous S5A protein revealed that, similar to ID1, a fraction of cellular S5A is localized at centrosomes. Similar centrosomal localization patterns have been reported for other components of the proteasome (Freed et al, 1999;Wigley et al, 1999;Fabunmi et al, 2000;Andersen et al, 2003), Localization of proteasome components at the centrosome might be crucial for centrosome duplication (reviewed in Hinchcliffe and Sluder, 2001). Supporting an important function of proteasome components during centrosome duplication are our findings that knockdown of S5A by shRNA caused an increase of cells with supernumerary centrioles (Figure 4).…”
Section: Discussionsupporting
confidence: 88%
“…The centrosome cycle itself also has control over cell cycle progression (Hinchcliffe and Sluder, 2001;Rieder et al, 2001;Stearns, 2001). During S phase, centrosome duplication takes place and at the onset of mitosis centrosomes separate forming two centrosomes, containing one mother and one daughter centriole .…”
Section: Centrosome Sister Chromatidmentioning
confidence: 99%
“…A normal centrosome consists of a pair of centrioles, short microtubule cylinders, embedded in pericentriolar material (Urbani and Stearns, 1999). The single centrosome duplicates precisely once before mitosis in order to form the two spindle poles (Hinchcliffe and Sluder, 2001). Centrosome duplication is synchronized with the cell division cycle and starts in late G1 phase with the splitting of the two centrioles.…”
Section: Introductionmentioning
confidence: 99%