Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure

Ferrante, Daniela; Chellini, Elisabetta; Merler, Enzo; Pavone, Venere; Silvestri, Stefano; Miligi, Lucia; Gorini, Giuseppe; Bressan, Vittoria; Girardi, Paolo; Ancona, Laura; Romeo, Elisa; Luberto, Ferdinando; O, Sala; Scarnato, Corrado; Menegozzo, Simona; Oddone, Enrico; Tùnesi, Sara; Perticaroli, Patrizia; Pettinari, Aldo; Cuccaro, Francesco; Mattioli, Stefano; Baldassarre, Antonio; Barone-Adesi, Francesco; Cena, Tiziana; Legittimo, Patrizia; Marinaccio, Alessandro; Mirabelli, Dario; Musti, Marina; Pirastu, Roberta; Ranucci, Alessandra; Magnani, Corrado

doi:10.1136/oemed-2016-104100

Cited by 52 publications

(51 citation statements)

References 31 publications

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“…Additionally, the features of the three cases of peritoneal mesothelioma of this cluster confirm that the risk increases according to the power of the time since first exposure (TSFE) [50] and are in agreement with previous studies [51,52].…”

Section: Discussionsupporting

confidence: 91%

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

Vimercati

Cavone

Delfino

et al. 2020

IJERPH

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The study describes a cluster of 71 malignant mesothelioma cases among Bari residents without asbestos exposure other than residential exposure. This small cohort, as expected, was composed of a majority of females (56.34%) with a M/F ratio of 0.8, ages ≤ 65 years old (52.11%) and the epithelioid morphological type (78.87%). Sixty-four subjects (90.14%) lived between 10 m and 1000 m from the asbestos cement factory (Fibronit), and the latency length was longer than 55 years for 25 subjects (35.21%). The adjusted risk (adjusted OR) of observing the epithelial form of mesothelioma among subjects living at small distances from Fibronit was high (OR = 1.870 (0.353–9.905)) for people living 550–1000 m from the site and for those living less than 550 m from the site (OR = 1.470 (0.262–8.248)). Additionally, the subjects with a high length of exposure showed a relevant risk of epithelioid mesothelioma both for 21–40 years of exposure (OR = 2.027 (0.521–7.890)) and more than 40 years of exposure (OR = 2.879 (0.651–12.736)). All of the estimates were high but not significant because this transitional study has a typically low power. The adjustment for latency showed the same trend. Using detailed information collected by the regional mesothelioma registry, this study provided evidence of a continuing health impact of the Fibronit asbestos cement factory in Bari on the resident population.

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Section: Discussionsupporting

confidence: 91%

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

Vimercati

Cavone

Delfino

et al. 2020

IJERPH

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“…This analysis did not demonstrate a correlation between mesothelioma incidence and duration of exposure (27). Similar results on the role of latency were obtained by another pooled analysis on several Italian cohorts (28).…”

Section: Effects Of Previous Occupational Exposuresupporting

confidence: 73%

Exposure to asbestos: past, present and future

Pira¹,

Donato²,

Maida³

et al. 2018

J. Thorac. Dis.

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“…It is remarkable that mesothelioma occurrence resulted higher than expected also in sites for which asbestos was not explicitly cited as contaminant in the official documents. The analysis of Italian pool of asbestos exposed workers' cohorts (43 evaluated cohorts including 51,081 subjects) has provided evidence of a flattening of pleural MM mortality risk after long time since first exposure (around 40 years) (19). According to an inclusive econometric model, elsewhere described in details (20), an estimate of 33,000 and 25,000 euros per patient for medical care costs and for insurance and compensation costs respectively, has been provided.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of malignant mesothelioma in Italy: surveillance systems, territorial clusters and occupations involved

Marinaccio¹,

Binazzi²,

Bonafede³

et al. 2018

J. Thorac. Dis.

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Background: As a legacy of the large asbestos consumption until the definitive ban in 1992, Italy is currently suffering a severe epidemic of asbestos related diseases. The aim of this paper is to describe the surveillance system for mesothelioma incidence and to provide evidences regarding the occurrence of the disease in Italy and the circumstances of asbestos exposure. occupational exposure has been defined for around 70% of interviewed cases (14,818). Non-occupational exposure is still relevant with 4.9% and 4.4% of cases for which respectively a familial exposure (due to the cohabitation with an occupational exposed subject) and an environmental exposure (due to the residence near a contaminated site) has been detected. Discussion:The epidemiological surveillance of MM incident cases, by the means of a national register for estimating the occurrence of the disease and identifying the circumstances of asbestos exposure, is a relevant tool for preventing asbestos exposure, for supporting the effectiveness of insurance system and for estimating reliable epidemiological figures.

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Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure

Abstract: The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. Pleural cancer mortality reached a plateau at long TSFE, coherently with recent reports.

Cited by 52 publications

References 31 publications

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

Asbestos Air Pollution: Description of a Mesothelioma Cluster Due to Residential Exposure from an Asbestos Cement Factory

Exposure to asbestos: past, present and future

Epidemiology of malignant mesothelioma in Italy: surveillance systems, territorial clusters and occupations involved

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