Item-location binding in working memory: Is it hippocampus-dependent?

Allen, Richard J.; Vargha‐Khadem, Faraneh; Baddeley, Alan

doi:10.1016/j.neuropsychologia.2014.04.013

Cited by 63 publications

(46 citation statements)

References 61 publications

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“…The possibility that working-memory processing leads to long-term memory formation is shown by arrow 3 between the "representation" and "consolidation" ellipses in Figure 1. At the same time, it must be noted that patients with MTL lesions can perform well on tests of working-memory maintenance, even when the task situation requires binding of items with locations (Allen et al 2014), but they show impairment if the material to be learned exceeds working-memory capacity (Jeneson and Squire 2012). These data highlight the dynamic relation between working memory and long-term memory.…”

Section: How Is Information In Working Memorymentioning

confidence: 95%

Working Memory: Maintenance, Updating, and the Realization of Intentions

Nyberg

Eriksson

2015

Cold Spring Harb Perspect Biol

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Correspondence: lars.nyberg@umu.se "Working memory" refers to a vast set of mnemonic processes and associated brain networks, relates to basic intellectual abilities, and underlies many real-world functions. Workingmemory maintenance involves frontoparietal regions and distributed representational areas, and can be based on persistent activity in reentrant loops, synchronous oscillations, or changes in synaptic strength. Manipulation of content of working memory depends on the dorsofrontal cortex, and updating is realized by a frontostriatal '"gating" function. Goals and intentions are represented as cognitive and motivational contexts in the rostrofrontal cortex. Different working-memory networks are linked via associative reinforcement-learning mechanisms into a self-organizing system. Normal capacity variation, as well as workingmemory deficits, can largely be accounted for by the effectiveness and integrity of the basal ganglia and dopaminergic neurotransmission.

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Section: How Is Information In Working Memorymentioning

confidence: 95%

Working Memory: Maintenance, Updating, and the Realization of Intentions

Nyberg

Eriksson

2015

Cold Spring Harb Perspect Biol

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“…Comparable performance patterns have been found between reconstruction tasks and the widely-used single probe recognition tasks (Allen, Vargha-Khadem, et al, 2014). Reconstruction tasks were chosen over single probe recognition tasks in the current study because the former potentially provide a measure of memory for every item in each of the sequence (Allen, Vargha-Khadem, et al, 2014). Therefore, compared to single probe tasks, reconstruction tasks can obtain sensitive data via relatively less number of trials, and as such, provide a measure that is more accessible to young children.…”

mentioning

confidence: 85%

“…Procedure. A reconstruction task used in previous research (Allen, Vargha-Khadem, et al, 2014;Jeneson et al, 2010) was adapted for the purposes of this study to measure working memory for visual and auditory-verbal information binding. In order to be able to separate participantsÕ memory capacity for individual elements from their ability to form associations between elements in working memory, two corresponding feature memory tasks were also administered to measure memory for constituent visual and auditory-verbal elements.…”

Section: Working Memory Task For Bindingmentioning

confidence: 99%

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confidence: 99%

“…This task paradigm has been successfully used to investigate the ability to create temporary bound representations in working memory in clinical patients (Allen, Vargha-Khadem, et al, 2014;Jeneson et al, 2010). Comparable performance patterns have been found between reconstruction tasks and the widely-used single probe recognition tasks (Allen, Vargha-Khadem, et al, 2014). Reconstruction tasks were chosen over single probe recognition tasks in the current study because the former potentially provide a measure of memory for every item in each of the sequence (Allen, Vargha-Khadem, et al, 2014).…”

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confidence: 99%

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Evaluating the developmental trajectory of the episodic buffer component of working memory and its relation to word recognition in children

Wang

Allen

Lee

et al. 2015

Journal of Experimental Child Psychology

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The creation of temporary bound representation of information from different sources is one of the key abilities attributed to the episodic buffer component of working memory. Whereas the role of working memory in word learning has received substantial attention, very little is known about the link between the development of word recognition skills and the ability to bind information in the episodic buffer of working memory, and how it may develop with age.This study examined the performance of Grade 2 (8 yrs old) and Grade 3 (9 yrs old) children and young adults on a task designed to measure their ability to bind visual and auditory-verbal information in working memory. ChildrenÕs performance on this task significantly correlated with their word recognition skills even when chronological age, memory for individual elements, and other possible reading-related factors were taken into account. In addition, clear developmental trajectories were observed, with improvements in the ability to hold temporary bound information in working memory between Grades 2 and 3, and between the children and adult groups, that were independent from memory for the individual elements. These findings suggest that the capacity to temporarily bind novel auditory-verbal information to visual form in working memory is linked to the development of word recognition in children, and improves with age.

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Reconstructing relational information

et al. 2017

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Hippocampal involvement in learning and remembering relational information has an extensive history, often focusing specifically on spatial information. In humans, spatial reconstruction (SR) paradigms are a powerful tool for evaluating an individuals' spatial-relational memory. In SR tasks, participants study locations of items in space and subsequently reconstruct the studied display after a short delay. Previous work has revealed that patients with hippocampal damage are impaired both in overall placement accuracy as well as on a specific measure of relational memory efficacy, "swaps" (i.e., when the relative location of two items is reversed). However, the necessity of the hippocampus for other types of spatial-relational information involved in reconstruction behaviors (e.g., where in the environment and relative to which other items an item was located) have not yet been investigated systematically. In this work, three patients with hippocampal damage and nine healthy matched comparison participants performed an SR task. An analysis framework was developed to independently assess three first-order types of relations: (1) memory for the binding of specific item identities to locations, (2) memory for arrangement of items in relation to each other or the environment bounds, regardless of memory for the item identity, and (3) higher-order, compound relational errors (i.e., errors involving multiple pieces of relational information). Reconstruction errors were evaluated to determine the degree to which patients and comparisons differed (or not) on each type of spatial-relational information. Data revealed that the primary group difference in performance was for identity-location information. However, when the locations of items were evaluated without regarding the identities, no group difference was found in the number of item placements to studied locations. The present work provides a principled approach to analysis of SR data and clarifies our understanding of the types of spatial relations impaired in hippocampal damaged.

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Item-location binding in working memory: Is it hippocampus-dependent?

Cited by 63 publications

References 61 publications

Working Memory: Maintenance, Updating, and the Realization of Intentions

Working Memory: Maintenance, Updating, and the Realization of Intentions

Evaluating the developmental trajectory of the episodic buffer component of working memory and its relation to word recognition in children

Reconstructing relational information

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