Items of the Montgomery-Åsberg Depression Rating Scale Associated With Response to Paroxetine Treatment in Patients With Major Depressive Disorder

Tomita, Tetsu; Sato, Yasushi; Nakagami, Taku; Tsuchimine, Shoko; Kaneda, Ayako; Kaneko, Sunao; Nakamura, Kazuhiko; Yasui‐Furukori, Norio

doi:10.1097/wnf.0000000000000146

Cited by 2 publications

(1 citation statement)

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“…It has good affinity with 5-HT receptor and can selectively inhibit the re-uptake of 5-HT, effectively block the recovery of 5-HT, and combine with olanzapine to make up for its weak effect on schizophrenia with negative symptoms. 19 Olgiati et al has reported that paroxetine had significant effect in the treatment of geriatric depression. 20 The results of the present study showed that the scores of negative factor, PANSS and HAMD of the observation group decreased after treatment and were significantly better than those of the control group, indicating that olanzapine combined with paroxetine could effectively improve the therapeutic effect in the treatment of schizophrenia and play a coordinated role, which was similar to the results of Reavley et al 21 Moreover the observation of adverse reactions demonstrated that there was no significant difference in the adverse reactions between the two groups, suggesting that the combined use of drugs had no influence on the safety.…”

Section: Discussionmentioning

confidence: 99%

Paroxetine combined with olanzapine in the treatment of schizophrenia

et al. 2020

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Objective: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. Methods: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as research subjects and randomly divided into observation group and control group using random number table, 42 cases in each group. The control group was treated with olanzapine orally, while the observation group was treated with olanzapine and paroxetine orally. The level of homocysteine (Hcy) in the two groups was analyzed before and after treatment. The efficacy was evaluated by the Positive and Negative Symptoms Scale (PANSS) score and Hamilton Depression Scale (HAMD) score. The adverse reactions of the two groups were compared. Results: After treatment, the level of serum Hcy in the observation group was significantly lower than that in the control group (P<0.05), and it was close to the normal level. There was no significant difference in PANSS score between the two groups before treatment (P>0.05). After treatment, the negative factor score and PANSS score in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The HAMD score of the two groups had no significant difference before treatment (P>0.05). After treatment, the HAMD score of the observation group was significantly lower than that of the control group (P<0.05). The difference of incidence of adverse reactions between the two groups had no statistical significance (P>0.05). Conclusion: Paroxetine combined with olanzapine has a definite clinical effect in the treatment of senile schizophrenia with depression. It can effectively reduce the level of serum Hcy, relieve the symptoms of schizophrenia, and alleviate the depressive symptoms of patients, with high safety. It is worth promoting. doi: https://doi.org/10.12669/pjms.36.3.846 How to cite this:Wang N, Zheng N, Dong M, He J. Paroxetine combined with olanzapine in the treatment of schizophrenia. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.846 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%