ITF expression in mouse brain during acquisition of alcohol self-administration

Ryabinin, Andrey E.; Bachtell, Ryan K.; Freeman, Pierre; Risinger, Fred O.

doi:10.1016/s0006-8993(00)03251-0

Cited by 41 publications

(40 citation statements)

References 13 publications

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“…Surprisingly, drinking sucrose induced a pattern of c-Fos activation similar to alcohol. This pattern was different from the one observed in waterdrinking controls (414).…”

Section: Ethyl Alcohol and C-fos Expressioncontrasting

confidence: 93%

“…Moreover, in another study of Ryabinin et al (416), in the same model of alcohol administration, no c-Fos activation was observed in any of the analyzed nuclei of the amygdala (basolateral, lateral, and medial part of the central) following repeated alcohol drinking, compared with water-or sucrose-drinking animals. The only described difference in procedures was that the animals received alcohol either during the dark (416) or light phase of a day (414). Additionally, Sharpe et al (442) showed that chronic alcohol drinking led to the decreased c-Fos protein expression level in the basolateral nucleus, compared with water-drinking animals.…”

Section: Ethyl Alcohol and C-fos Expressionmentioning

confidence: 99%

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Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

Knapska¹,

Radwańska²,

Werka³

et al. 2007

Physiological Reviews

141

134

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The amygdala is a heterogeneous brain structure implicated in processing of emotions and storing the emotional aspects of memories. Gene activity markers such as c-Fos have been shown to reflect both neuronal activation and neuronal plasticity. Herein, we analyze the expression patterns of gene activity markers in the amygdala in response to either behavioral training or treatment with drugs of abuse and then we confront the results with data on other approaches to internal complexity of the amygdala. c-Fos has been the most often studied in the amygdala, showing specific expression patterns in response to various treatments, most probably reflecting functional specializations among amygdala subdivisions. In the basolateral amygdala, c-Fos expression appears to be consistent with the proposed role of this nucleus in a plasticity of the current stimulus-value associations. Within the medial part of the central amygdala, c-Fos correlates with acquisition of alimentary/gustatory behaviors. On the other hand, in the lateral subdivision of the central amygdala, c-Fos expression relates to attention and vigilance. In the medial amygdala, c-Fos appears to be evoked by emotional novelty of the experimental situation. The data on the other major subdivisions of the amygdala are scarce. In conclusion, the studies on the gene activity markers, confronted with other approaches involving neuroanatomy, physiology, and the lesion method, have revealed novel aspects of the amygdala, especially pointing to functional heterogeneity of this brain region that does not fit very well into contemporarily active debate on serial versus parallel information processing within the amygdala.

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“…Surprisingly, drinking sucrose induced a pattern of c-Fos activation similar to alcohol. This pattern was different from the one observed in waterdrinking controls (414).…”

Section: Ethyl Alcohol and C-fos Expressioncontrasting

confidence: 93%

Section: Ethyl Alcohol and C-fos Expressionmentioning

confidence: 99%

Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse

Knapska¹,

Radwańska²,

Werka³

et al. 2007

Physiological Reviews

141

134

View full text Add to dashboard Cite

show abstract

“…These data are consistent with previous findings showing ethanol-induced increases in the CeL and PV (Chang et al, 1995;Hitzemann and Hitzemann, 1997;Ryabinin et al, 1997). Increased FOS expression in the EW of ethanol-tested mice was expected on the basis of several previous reports in both rats (Chang et al, 1995;Ryabinin et al, 1997;Topple et al, 1998;Weitemier et al, 2001) and mice (Bachtell et al, 1999(Bachtell et al, , 2002Ryabinin et al, 2001Ryabinin et al, ,2003. It is important to note that the mouse EW (identified based on morphological criteria) does not contain preganglionic parasympathetic neurons and is involved in regulation of non-ocular functions (Bachtell et al, ,2004Ryabinin and Weitemier, 2006;Weitemier et al, 2005).…”

Section: Ethanol Effects On Fos Expressionsupporting

confidence: 92%

FOS expression induced by an ethanol-paired conditioned stimulus

Hill

Ryabinin

Cunningham

2007

Pharmacology Biochemistry and Behavior

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To identify brain areas involved in ethanol-induced Pavlovian conditioning, brains of male DBA/2J mice were immunohistochemically analyzed for FOS expression after exposure to a conditioned stimulus (CS) previously paired with ethanol (2 g/kg) in two experiments. Mice were trained with a procedure that normally produces place preference (Before: ethanol before the CS) or one that normally produces place aversion (After: ethanol after the CS). Control groups received unpaired ethanol injections in the home cage (Delay) or saline only (Naïve). On the test day, mice were exposed to the 5-min CS 90 min before sacrifice. Before groups showed a conditioned increase in activity, whereas the After group showed a conditioned decrease in activity. FOS expression after a drug-free CS exposure was significantly higher in Before-group mice than in control mice in the bed nucleus of the stria terminalis (Exp. 1) and anterior ventral tegmental area (Exps. 1-2). Conditioned FOS responses were also seen in areas of the extended amygdala and hippocampus (Exp. 2). However, no conditioned FOS changes were seen in any brain area examined in After-group mice. Overall, these data suggest an important role for the mesolimbic dopamine pathway, extended amygdala and hippocampus in ethanol-induced conditioning.

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“…Brain regions changing activity after drinking of alcohol-containing solutions have been mapped by analyzing expression of inducible transcription factors (ITFs) (Topple et al 1998;Bachtell et al 1999;Ryabinin et al 1999Ryabinin et al , 2001Weitemier et al 2001). This approach is based on the notion that basal expression of ITFs (c-Fos, c-Jun, JunB, Zif268 and several others) in neurons is very low but, upon stimulation of the neurons (including actions of agents leading to neuronal depolarization), a rapid transient induction of these proteins occurs (Morgan et al 1987;Sagar et al 1988).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies show that voluntary self-administration of an alcohol-containing solution produces a distinct pattern of c-Fos expression from involuntary alcohol administration (Topple et al 1998;Bachtell et al 1999;Ryabinin et al 1999Ryabinin et al , 2001Weitemier et al 2001). One effect most frequently observed in such studies is induction of c-Fos in the Edinger-Westphal nucleus (EW).…”

Section: Introductionmentioning

confidence: 99%