ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors

Abstract

Integrins are a class of a cell surface adhesion molecule which composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Its main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functions, such as tumor cell proliferation, adhesion, invasion, and angiogenesis. But its abnormal expression mechanism in cancer and its specific role in tumor growth and metastasis are still unknown to a great extent. This review reveals the role of ITGA9 in the complex pathogenesis of many tumors and cancers, providing a new direction for the treatment of tumors and cancers. Relevant studies were retrieved and collected through the PubMed system. After determining ITGA9 as the research object, we found the close relationship between ITGA9 and tumorigenesis through the analysis of the research articles on ITGA9 in the PubMed system in the last 15 years, and further determined the references mainly based on the influencing factors of the articles. Thus, the role of ITGA9 in tumor and cancer genesis, proliferation, and metastasis was reviewed and analyzed. ITGA9 is an integrin subunit, which has been proved to be abnormally expressed in many tumors. After sorting and analyzing the research data, it was found that the abnormal expression of ITGA9 in a variety of tumors, including glioblastoma, rhabdomyosarcoma, melanoma, hepatocellular carcinoma, nasopharyngeal carcinoma, multiple myeloma, non-small cell lung cancer, and prostate cancer, was closely related to the proliferation, metastasis, adhesion, and angiogenesis of tumor cells. These results suggest that ITGA9 plays an important role in the occurrence and development of tumors. The integrin subunit ITGA9 may serve as a biomarker for the diagnosis of tumors and a potential therapeutic target for anti-tumor therapies.

Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosis

“…Tumors that are highly angiogenic and poorly invasive exhibit low levels of β8 integrin, whereas highly invasive tumors with limited neovascularization express high levels of β8 integrin (Tchaicha et al, 2011). Abnormal expression of ITGA9 was observed in various tumors including GBM and is closely related to tumor proliferation and angiogenesis (Wu et al, 2022). Furthermore, overexpression of ITGA3/ITGB1 plays a central role in promoting tube formation in tumor-associated EC in GBM.…”

Exploration of Molecular Mechanisms of Immunity in the Pacific Oyster (Crassostrea gigas) in Response to Vibrio alginolyticus Invasion

“…CDC42 acts as a regulatory factor to control the production of functional granulocytes in the oyster, thereby regulating the phagocytosis of hemocytes [ 73 ]. ITGA9 is a subunit of integrin, a cell surface receptor that plays a crucial role in promoting cell migration and regulating various cellular biological functions, including tumor cell proliferation, adhesion, and invasion [ 74 ]. PLG is a key regulatory protein that both promotes fibrinolysis during the wound healing process and aids in rapid wound healing, as well as neutrophil apoptosis and efferocytosis to reduce inflammation [ 75 ].…”

Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3

“…Integrins are a type of heterodimeric transmembrane glycoprotein that consists of α subunits (ITGA) and β subunits (ITGB). They act as receptors for cell adhesion molecules (CAMs) and the extracellular matrix (ECM) (Wu et al, 2022). As a member of the integrin family, ITGA9 plays multiple cellular and biological roles, including promoting cell migration and regulating tumour cell proliferation, adhesion, invasion and angiogenesis (Wu et al, 2022).…”

“…They act as receptors for cell adhesion molecules (CAMs) and the extracellular matrix (ECM) (Wu et al, 2022). As a member of the integrin family, ITGA9 plays multiple cellular and biological roles, including promoting cell migration and regulating tumour cell proliferation, adhesion, invasion and angiogenesis (Wu et al, 2022). However, its effect on stem cell ageing remains unclear.…”