iTRAQ based investigation of plasma proteins in HIV infected and HIV/HBV coinfected patients — C9 and KLK are related to HIV/HBV coinfection

Sun, Tao; Liu, Li; Wu, Ao; Zhang, Yujiao; Jia, Xiaofang; Li, Yin; Lu, Hongzhou; Zhang, Lijun

doi:10.1016/j.ijid.2017.08.006

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…Some of these pathways were already identified using integrative multiomics analyses (whole genome and transcriptome sequencing) in the context of the identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma 23 . Other studies investigated HCV or HBV infection and response to therapy using micro RNAs networks 24 , transcriptomics 25 , proteomics 26–28 . However, a direct comparison with the present results is difficult due the different study designs and the different clinical settings.…”

Section: Discussionmentioning

confidence: 99%

The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy

Lorini

Monti

Madia

et al. 2019

Sci Rep

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Few studies are available on metabolic changes in liver injuries and this is the first metabolomic study evaluating a group of HCV-positive patients, before and after viral eradication via DAA IFN-free regimens, using 1H-NMR to characterize and compare their serum fingerprints to naïve HBV-patients and healthy donors. The investigation clearly shows differences in the metabolomic profile of HCV patients before and after effective DAA treatment. Significant changes in metabolites levels in patients undergoing therapy suggest alterations in several metabolic pathways. It has been shown that 1H-NMR fingerprinting approach is an optimal technique in predicting the specific infection and the healthy status of studied subjects (Monte-Carlo cross validated accuracies: 86% in the HCV vs HBV model, 98.7% in the HCV vs HC model). Metabolite data collected support the hypothesis that the HCV virus induces glycolysis over oxidative phosphorylation in a similar manner to the Warburg effect in cancer, moreover our results have demonstrated a different action of the two viruses on cellular metabolism, corroborating the hypothesis that the metabolic perturbation on patients could be attributed to a direct role in viral infection. This metabolomic study has revealed some alteration in metabolites for the first time (2-oxoglutarate and 3-hydroxybutrate) concerning the HCV-infection model that could explain several extrahepatic manifestations associated with such an infection.

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Section: Discussionmentioning

confidence: 99%

The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy

Lorini

Monti

Madia

et al. 2019

Sci Rep

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“…Viruses that cause chronic infection have also been related to neuroinflammatory states; among them, the acquired immunodeficiency virus type 1 (HIV-1) and the hepatitis B virus (HBV;Aygören-Pürsün et al, 2016;Sun et al, 2017) may have some unexplored relation with KLKs. HIV-infection in the CNS is a significant step of systemic infection that can be detected shortly after primary exposure and initial viremia (Davis et al, 2012).…”

Section: Klks Associated To Viral Infections That Can Affect the Cnsmentioning

confidence: 99%

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Mella

Figueroa

Otth

et al. 2020

Front. Cell. Neurosci.

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Kallikrein-related peptidases (KLKs) are a family of serine proteases that when dysregulated may contribute to neuroinflammation and neurodegeneration. In the present review article, we describe what is known about their physiological and pathological roles with an emphasis on KLK6 and KLK8, two KLKs that are highly expressed in the adult central nervous system (CNS). Altered expression and activity of KLK6 have been linked to brain physiology and the development of multiple sclerosis. On the other hand, altered levels of KLK6 in the brain and serum of people affected by Alzheimer's disease and Parkinson's disease have been documented, pointing out to its function in amyloid metabolism and development of synucleinopathies. People who have structural genetic variants of KLK8 can suffer mental illnesses such as intellectual and learning disabilities, seizures, and autism. Increased expression of KLK8 has also been implicated in schizophrenia, bipolar disorder, and depression. Also, we discuss the possible link that exists between KLKs activity and certain viral infections that can affect the nervous system. Although little is known about the exact mechanisms that mediate KLKs function and their participation in neuroinflammatory and neurodegenerative disorders will open a new field to develop novel therapies to modulate their levels and/or activity and their harmful effects on the CNS.

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“…Method validation was performed according to Chinese pharmacopoeia 2015, and FDA guidelines [15]. The method was validated for selectivity, carryover, linearity, accuracy, precision, matrix effect, recovery, and stability.…”

Section: Methods Validationmentioning

confidence: 99%

Pharmacokinetic Study of Ethambutol and Amikacin in Rat Lung Tissue Detected by UPLC-MS Method

Li¹,

Shi

Chen

et al. 2021

BJSTR

Self Cite

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Lower drug concentrations at tuberculosis (TB) infection sites may result in drug resistance. Understanding the tissue penetration of anti-TB drugs will offer new clues for optimizing drug dose. In this work, we performed pharmacokinetic study of ethambutol (EMB) and amikacin (AMK) in rat lung. Herein, a total of 160 rats were randomized to 16 time points, including before dosing (0h), and after dosing 0.

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iTRAQ based investigation of plasma proteins in HIV infected and HIV/HBV coinfected patients — C9 and KLK are related to HIV/HBV coinfection

Cited by 8 publications

References 40 publications

The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy

The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy

Involvement of Kallikrein-Related Peptidases in Nervous System Disorders

Pharmacokinetic Study of Ethambutol and Amikacin in Rat Lung Tissue Detected by UPLC-MS Method

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