Itrathecal Meperidine for Pain after Cesarean Delivery

Feldman, Jennifer; Griffin, F.; Fermo, Leonda; Raessler, Kenneth L.

doi:10.1097/00000542-199209001-01011

Cited by 2 publications

(1 citation statement)

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“…Investigations of the addition of pethidine to conventional local anaesthetic for spinal anaesthesia for caesarean section have shown that early postoperative analgesia is improved. Feldman et al found that addition of pethidine 10 mg to bupivacine 12 mg resulted in lower pain scores and reduced requirement for supplementary analgesia at 2 h compared with saline control 51 . Increasing the dose of pethidine to 20 mg caused more side-effects without improving analgesia.…”

Section: Postoperative Analgesiamentioning

confidence: 99%

Intrathecal Pethidine: Pharmacology and Clinical Applications

Kee

1998

Anaesth Intensive Care

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Pethidine is the only member of the opioid family that has clinically important local anaesthetic activity in the dose range normally used for analgesia. Pethidine is unique as the only opioid in current use that is effective as the sole agent for spinal anaesthesia. In lower doses, intrathecal pethidine is also an effective analgesic for treating pain in labour. This paper reviews the pharmacology of intrathecal pethidine and clinical experience reported to date. Articles reviewed include those identified by a Medline search using keywords "intrathecal" or "spinal anaesthesia/ anesthesia" and "pethidine" or "meperidine". Reference lists from identified papers were scrutinized to identify further relevant articles.

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Section: Postoperative Analgesiamentioning

confidence: 99%