IUI and uterine lavage of in vivo–produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?

Santis, Lucia De; Cimadomo, Danilo; Capalbo, Antonio; Pietro, Cinzia Di; Zuccarello, Daniela; Anastasi, Attilio; Licata, Emanuele; Scarica, Catello; Fernandez, Laura Sosa; Klinger, Francesca Gioia

doi:10.1007/s10815-020-01813-7

Cited by 3 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, 24 out of 96 blastocysts have been obtained by additional embryo cultivation. This has already been pointed out in a previous opinion paper [4]. It is also important to note that uterine lavage does not mitigate the risks associated with ovarian stimulation.…”

Section: Benefit-risk Assessmentmentioning

confidence: 82%

“…Human experiments should be based on previous animal experimentation. 4. Experiments should be conducted by avoiding physical/ mental suffering and injury.…”

Section: Discussionmentioning

confidence: 99%

“…embryos (for PGT) is really required. Whereas De Santis et al primarily discussed the shortcomings of technical aspects and concluded that the work of Munné and colleagues cannot be considered relevant in ART because of its technical limitations [4], we think that the moral and ethical impact of this study are of much broader extent (as explained in detail below).…”

Section: Introductionmentioning

confidence: 86%

See 2 more Smart Citations

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

Murtinger

Wirleitner

Hradecký³

et al. 2020

J Assist Reprod Genet

View full text Add to dashboard Cite

A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage (uterine flushing) and subjected to genetic testing for aneuploidies (PGT-A). Oocyte donors with persistently elevated hCG levels, indicating the implantation of one or more embryos after uterine lavage, had to undergo uterine curettage and/or treatment with methotrexate. A critical opinion paper discussing the aforementioned study was published by De Santis and colleagues and has raised critical issues that are largely technical in nature. However, this opinion paper neglects-from our point of view-critical issues of the Mexican study regarding ethical principles and moral standards in human research. These aspects are summarized below.

show abstract

Section: Benefit-risk Assessmentmentioning

confidence: 82%

“…Human experiments should be based on previous animal experimentation. 4. Experiments should be conducted by avoiding physical/ mental suffering and injury.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

Murtinger

Wirleitner

Hradecký³

et al. 2020

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…This raised several ethical concerns about the Munné study. In May 2020, JARG published a critique of the study by De Santis et al Speaking for the leadership of the Italian Society of Embryology, Reproduction and Research (SIERR), the JARG article contended that the Munné study was "undermined by severe technical and ethical issues" [5].…”

mentioning

confidence: 99%

When pregnancy is a research risk

Green

2020

J Assist Reprod Genet

View full text Add to dashboard Cite

A published study reported by Munné using uterine lavage to retrieve in vivo blastocysts for preimplantation genetic testing has been the subject of several technical and ethical critiques. None of these critiques has been based on a review of the study's IRBapproved informed consent. This commentary seeks to do that, examining the Munné (and related Nadal) consent forms for their conformity to existing requirements for a full and informed consent.

show abstract

Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts

Najmabadi

Rivas²,

Angle

et al. 2023

Adv Ther

View full text Add to dashboard Cite

IUI and uterine lavage of in vivo–produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?

Cited by 3 publications

References 16 publications

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

When pregnancy is a research risk

Human Uterine Lavage: First Live Births from In Vivo Conceived Genetically Screened Blastocysts

Contact Info

Product

Resources

About