IV Brazilian Guidelines for autoantibodies on HEp-2 cells

Francescantônio, Paulo Luiz Carvalho; Cruvinel, Wilson de Melo; Dellavance, Alessandra; Andrade, Luís Eduardo Coelho; HurTaliberti, Ben; Mühlen, Carlos Alberto von; Bichara, Carlos David Araújo; Bueno, Cleonice; Mangueira, Cristóvão Luis Pitangueira; Carvalho, Darlene Gonçalves; Bonfá, Eloísa; Brito, Fabiano de Almeida; Araújo, Flávia Ikeda e; Rêgo, Jozélia; Pereira, Kaline Medeiros Costa; Anjos, Lisiane Maria Enriconi dos; Bissoli, Maria de Fatima; Santiago, Mittermayer Barreto; Maluf, Natalya Zaidan; Alvarenga, Rossana Rassi; Neves, Suzane Pretti Figueiredo; Valim, Valéria; Santos, Wilton Silva dos

doi:10.1016/j.rbre.2014.02.006

Cited by 21 publications

(43 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Madrid et al [5] found a much higher prevalence (up to 99% in invasive breast cancer), but these authors combined the HEp-2 cells immunofluorescence technique with immunoblot of breast cancer proteins, broadening their field of investigation. A homogeneous pattern is often linked to anti-dsDNA, anti-nucleosome and antihistone antibodies, while fine-speckled is linked to anti-Ro and anti-La antibodies; coarse-speckled is linked to anti-RNP and anti-Sm antibodies [20]. Some of the currently studied patients had immunofluorescence patterns that are highly valued in rheumatology clinics, such as homogeneous, nucleolar, fine-and coarsespeckled and nucleolar patterns.…”

Section: Discussionmentioning

confidence: 98%

“…Although extremely interesting from a research viewpoint, this last technique is not available in current daily clinical practice. A nucleolar pattern is seen frequently in scleroderma patients and may indicate the presence of anti-Scl-70 (or anti-topoisomerase-1) [20]. A homogeneous pattern is often linked to anti-dsDNA, anti-nucleosome and antihistone antibodies, while fine-speckled is linked to anti-Ro and anti-La antibodies; coarse-speckled is linked to anti-RNP and anti-Sm antibodies [20].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-nuclear antibodies in patients with breast cancer

Nisihara

Machoski

Neppel

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

To study the prevalence of anti-nuclear antibodies (ANA) in breast cancer patients and its association with tumour characteristics. Ninety-one patients with breast mass detected by image studies and assigned to conduct diagnostic biopsy and eventual surgical treatment were studied for demographical, tumour data and presence of ANA. Serum of positive ANA patients was screened for the extractable nuclear antigen (ENA) profile. As comparison, 91 healthy individuals matched for age and from the same geographical area were included. In this sample 72 of 91 (79·1%) had malignant lesions (83% ductal infiltrative carcinoma). ANA was positive in 44·4% of patients with malignant tumour and in 15·7% of those with benign lesions (malignant versus benign with P = 0·03). Controls had ANA positivity in 5·4%, and when compared with tumour samples showed P < 0·0001. The most common immunofluorescence pattern was a fine dense speckled pattern. In the ANA-positive patients with malignant lesions, seven had positivity for ENA profile (three for anti-RNP and anti-Sm, one for just anti-RNP, two for anti-Ro and anti-La e two for just anti-La). It was not possible to associate ANA positivity with tumour histological characteristics or staging or with patient's age. A negative association of ANA with hormonal (oestrogen or oestrogen plus progesterone) receptor status was found (P = 0·01). In this sample, there was a high prevalence of ANA positivity in breast cancer patients with a negative association with the presence of hormonal receptors. More studies are needed to understand the real value of this finding.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Anti-nuclear antibodies in patients with breast cancer

Nisihara

Machoski

Neppel

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…revealing mixed patterns. In Brazil there is already a longstanding activity towards developing guidelines for patterns revealed by autoantibodies on HEp-2 cells, the standard substrate for ANA detection [46]. Also, a recommended nomenclature for ANA patterns has been published [47].…”

Section: International Consensus On Ana Patterns (Icap)mentioning

confidence: 99%

Autoantibodies 2015: From diagnostic biomarkers toward prediction, prognosis and prevention

Damoiseaux¹,

Andrade²,

Fritzler³

et al. 2015

Autoimmunity Reviews

View full text Add to dashboard Cite

“…AMA should be tested initially by II in rodent tissue and HEp2 cells, as these are available and standardized tests in our country (122) . This marker is positive in 90%95% of patients.…”

mentioning

confidence: 99%

“…Detection of AMA positivity in patients without clinical or laboratory evidence of PBC may indicate a high probability of PBC being diagnosed within the next 10 years. AMA titers below 1:80 may be present in the normal population (<1%), and therefore should be interpreted with some caution (122,123) . Low titer AMA can be detected in oth er conditions, such as lupus, antiphospholipid syndrome, autoimmune hemolytic anemia, alcoholic liver disease and hepatitis C (4) .…”

mentioning

confidence: 99%

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

Bittencourt

Cançado

Couto

et al. 2015

Arq. Gastroenterol.

View full text Add to dashboard Cite

-In order to draw evidence-based recommendations concerning the management of autoimmune diseases of the liver, the Brazilian Society of Hepatology has sponsored a single-topic meeting in October 18th, 2014 at São Paulo. An organizing committee comprised of seven investigators was previously elected by the Governing Board to organize the scientific agenda as well as to select twenty panelists to make a systematic review of the literature and to present topics related to the diagnosis and treatment of autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis and their overlap syndromes. After the meeting, all panelists gathered together for the discussion of the topics and the elaboration of those recommendations. The text was subsequently submitted for suggestions and approval of all members of the Brazilian Society of Hepatology through its homepage. The present paper is the final version of the reviewed manuscript organized in topics, followed by the recommendations of the Brazilian Society of Hepatology.

show abstract

IV Brazilian Guidelines for autoantibodies on HEp-2 cells

Cited by 21 publications

References 24 publications

Anti-nuclear antibodies in patients with breast cancer

Anti-nuclear antibodies in patients with breast cancer

Autoantibodies 2015: From diagnostic biomarkers toward prediction, prognosis and prevention

Brazilian society of hepatology recommendations for the diagnosis and management of autoimmune diseases of the liver

Contact Info

Product

Resources

About