IV Delivery of Induced Pluripotent Stem Cells Attenuates Endotoxin-Induced Acute Lung Injury in Mice

Yang, Kuang Yao; Shih, Hsin Chin; How, Chorng–Kuang; Chen, Cheng-Yu; Hsu, Han Shui; Yang, Ching Wen; Lee, Yu Chin; Perng, Reury Perng; Peng, Chi Hsien; Li, Hsin Yang; Chang, Chia Ming; Mou, Chung‐Yuan; Chiou, Shih Hwa

doi:10.1378/chest.11-0539

Cited by 71 publications

(111 citation statements)

References 42 publications

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“…The first study to demonstrate the therapeutic potential and immunomodulatory effect of iPS cells in ALI was made by Yang et al [2011]. They discovered that iPS cells via intravenous injection migrated and accumulated in the area of lung injury, iPS cell administration diminished the pathologic severity of endotoxin-induced ALI, iPS cells improved the pulmonary physiologic functions, and finally, the advantageous effects with iPS cells were partly mediated by reducing the activity of NF-κB and paracrine factors not yet identified.…”

Section: Escs and Induced Pluripotent Stem Cellsmentioning

confidence: 99%

Paracrine Effects and Heterogeneity of Marrow-Derived Stem/Progenitor Cells: Relevance for the Treatment of Respiratory Diseases

Conese

Carbone

Castellani

et al. 2013

Cells Tissues Organs

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Stem cell-based treatment may represent a hope for the treatment of acute lung injury and pulmonary fibrosis, and other chronic lung diseases, such as cystic fibrosis, asthma and chronic obstructive pulmonary disease (COPD). It is well established in preclinical models that bone marrow-derived stem and progenitor cells exert beneficial effects on inflammation, immune responses and repairing of damage in virtually all lung-borne diseases. While it was initially thought that the positive outcome was due to a direct engraftment of these cells into the lung as endothelial and epithelial cells, paracrine factors are now considered the main mechanism through which stem and progenitor cells exert their therapeutic effect. This knowledge has led to the clinical use of marrow cells in pulmonary hypertension with endothelial progenitor cells (EPCs) and in COPD with mesenchymal stromal (stem) cells (MSCs). Bone marrow-derived stem cells, including hematopoietic stem/progenitor cells, MSCs, EPCs and fibrocytes, encompass a wide array of cell subsets with different capacities of engraftment and injured tissue-regenerating potential. The characterization/isolation of the stem cell subpopulations represents a major challenge to improve the efficacy of transplantation protocols used in regenerative medicine and applied to lung disorders.

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Section: Escs and Induced Pluripotent Stem Cellsmentioning

confidence: 99%

Paracrine Effects and Heterogeneity of Marrow-Derived Stem/Progenitor Cells: Relevance for the Treatment of Respiratory Diseases

Conese

Carbone

Castellani

et al. 2013

Cells Tissues Organs

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“…It has been demonstrated that these cells are active players in lung repair [36]. In spite of doubts about their safety and the best administration route to improve their engraftment, use of stem cells in animal models has been demonstrated to attenuate damage and fi brosis in lungs challenged with endotoxin [37]. In a recent study, Curley et al [38] submitted a group of rats to VILI followed by an intravenous injection of mesenchymal stem cells; these animals showed less lung injury and increased levels of the anti-infl ammatory and anti-fi brotic cytokine, IL-10, than did rats who did not receive the stem cells.…”

Section: Therapeutic Strategies Aimed At Lung Repairmentioning

confidence: 99%

Repair after Acute Lung Injury: Molecular Mechanisms and Therapeutic Opportunities

González-López¹,

Albaiceta²

2012

Annual Update in Intensive Care and Emergency Medicine 2012

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“…Studies performed on endotoxin-induced acute lung injury (ALI) in rodents have also shown that the intravenous delivery of iPSCs can provide a beneficial effect to attenuate the severity of ALI and improve the physiological impairment, which is partly attributed to NF-kB and neutrophil accumulation [25,26].…”

Section: Induced Pluripotent Stem Cellsmentioning

confidence: 99%

The Implications of Stem Cell Applications for Diseases of the Respiratory System

Lim

Jungebluth

Macchiarini

2012

Mesenchymal Stem Cells - Basics and Clinical Application II

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Stem cells possess the unique properties of unlimited self-renewal capability and a broad differentiation spectrum to produce multiple different cell types. This provides many platforms to explore novel multidisciplinary approaches to create and/or restore functional three-dimensional tissues or organs for the treatment of a range of diseases. In this chapter, in the context of respiratory diseases, we review the unique properties of stem cells, and how they have been studied for their therapeutic potential in cell therapy and tissue engineering. In addition, we give a brief overview of the current clinical studies on the use of stem cells for both acute and chronic respiratory diseases.

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IV Delivery of Induced Pluripotent Stem Cells Attenuates Endotoxin-Induced Acute Lung Injury in Mice

Cited by 71 publications

References 42 publications

Paracrine Effects and Heterogeneity of Marrow-Derived Stem/Progenitor Cells: Relevance for the Treatment of Respiratory Diseases

Paracrine Effects and Heterogeneity of Marrow-Derived Stem/Progenitor Cells: Relevance for the Treatment of Respiratory Diseases

Repair after Acute Lung Injury: Molecular Mechanisms and Therapeutic Opportunities

The Implications of Stem Cell Applications for Diseases of the Respiratory System

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