‘Iva-Sim’ an Interactive Computer Program to Simulate Intravenous Anesthesia

Schüttler, J.; Kloos, S.

doi:10.1097/00000542-199109001-00329

Cited by 3 publications

(2 citation statements)

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“…It is important to consider the effects that drugs other than those of nitrous oxide and isoflurane have on CBFV. In this regard, the pharmacokinetic profilc of the short-acting induction agent propofol used in this study makes it unlikely that this drug exerted an appreciablc effect on the cerebral vasculature (30). Alfentanil does not affect cerebral hemodynamics (3 1).…”

Section: Discussionmentioning

confidence: 88%

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Strebel

Kaufmann

Anselmi

et al. 1995

Acta Anaesthesiol Scand

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Nitrous oxide during neurosurgical procedures is almost always given in combination with either volatile or intravenous anesthetics. The modifying influence of such interventions has been studied clinically and in experimental settings; the reported findings, however, are inconsistent. The present study compares the cerebrovascular effects of MAC equivalent concentrations of isoflurane alone and isoflurane plus nitrous oxide. Twenty lumbar laminectomy patients randomized either to receive isoflurane or isoflurane plus nitrous oxide were investigated over a dose range from 0.5 to 1.5 MAC. A transcranial Doppler (TCD) ultrasonography device was used to measure cerebral blood flow velocity (CBFV) in the right middle cerebral artery (MCA) as an index of anesthetic-induced alterations in cerebral blood flow (CBF). A small but marginally significant decrease in CBFV at 1 MAC and no change at 1.5 MAC occurred in the isoflurane anesthetized patients. In contrast, a small but significant increase in CBFV at 1 MAC and a very significant increase at 1.5 MAC occurred in the isoflurane plus nitrous oxide anesthetized patients. Nitrous oxide added to an isoflurane anesthetic regimen is concluded to be a potent vasodilator. In addition, the vasodilating effects of nitrous oxide were not uniform; they progressively increased with an increasing isoflurane concentration.

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Section: Discussionmentioning

confidence: 88%

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Strebel

Kaufmann

Anselmi

et al. 1995

Acta Anaesthesiol Scand

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“…Propofol is a widely used anesthetic agent, therefore the achievement and maintenance of its particular concentration is of particular interest. Several software tools computing the required delivery rate based on changes of propofol concentration in blood has been developed in the past: STANPUMP [10], IVASIM [9] and RUGLOOP [12]. Some of these algorithms have been commercialised.…”

Section: Target Controlled Infusion Of Anaesthesiamentioning

confidence: 99%

Cascaded PID controller for anaesthesia delivery

Simalatsar

Guidi

Buclin

2016

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Abstract-The technologies for continuous measurement of the anaesthetic agents circulating in body fluids are not mature yet, though some preliminary prototypes exist already. We present a control algorithm that based on the real measurement of propofol plasma concentration may adjust the delivery rate. This opens a possibility for a safer anesthesia when the technologies for online measurement of drug concentration will be mature enough to be combined with our model.

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Thoracic Epidural Analgesia

Albrecht

2000

Semin Cardiothorac Vasc Anesth

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Thoracic epidural analgesia (TEA) offers a unique oppor tunity for the anesthesiologist to enhance postopera tive recovery for the thoracic surgery patient. By deliver ing analgesics to a limited dermatomal distribution, TEA can provide profound segmental analgesia and also serves to modulate neural outflow to improve cardiac and pulmonary parameters. The notable side-effects of hypotension and respiratory depression can be mini mized by using synergistic combinations of local anes thetic and opioids, and by adopting a continuous infu sion strategy. With thoughtful patient selection, careful technique, and a proactive approach to the recognition of the known hemodynamic and respiratory effects of epidural drugs, TEA can be administered safely. The significant benefits of TEA include better pain relief, increased FEV1, earlier extubation, and, perhaps, de creased morbidity and mortality.

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‘Iva-Sim’ an Interactive Computer Program to Simulate Intravenous Anesthesia

Cited by 3 publications

References 0 publications

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study

Cascaded PID controller for anaesthesia delivery

Thoracic Epidural Analgesia

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