2024
DOI: 10.3390/jcm13082338
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Ivabradine in Septic Shock: A Narrative Review

Marco Pasetto,
Lorenzo Antonino Calabrò,
Filippo Annoni
et al.

Abstract: In patients with septic shock, compensatory tachycardia initially serves to maintain adequate cardiac output and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation. This sustained elevation in heart rate and altered heart rate variability, indicative of autonomic dysfunction, is a well-established independent predictor of adverse outcomes in critical illness. Elevated heart rate exacerbates myocardial oxygen demand, reduces ventricular filling time, compromises coronary … Show more

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