Ivermectin and Moxidectin Can Incapacitate Different Strains of the Common Bed Bug Cimex lectularius L.: A Study

Sheele, Johnathan M.; Lesser, Elizabeth R.; Li, Xin; Schlatzer, Danie; Ridge, Gale E.

doi:10.7759/cureus.6714

Cited by 2 publications

(2 citation statements)

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“…This strategy has been broadly accepted for use in pets and companion animals. Studies that supplemented blood with insecticides in membrane-based artificial feeders have demonstrated considerable mortality in the common bed bug; effective active ingredients (AIs) include conventional insecticides, such as abamectin and fipronil [ 13 ], and antiparasitic drugs, such as ivermectin, moxidectin [ 14 ] and fluralaner [ 15 ]. In vivo xenointoxication was also shown to be effective on bed bugs that were fed on ivermectin-treated mice [ 16 ] and rabbits [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

et al. 2022

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Background The common bed bug, Cimexlectularius L., is a hematophagous ectoparasite that was a common pest in poultry farms through the 1960s. Dichlorodiphenyltrichloroethane (DDT) and organophosphates eradicated most infestations, but concurrent with their global resurgence as human ectoparasites, infestations of bed bugs have been reappearing in poultry farms. Although the impact of bed bugs on chicken health has not been quantified, frequent biting and blood-feeding are expected to cause stress, infections and even anemia in birds. Bed bug control options are limited due to the sensitive nature of the poultry environment, limited products labeled for bed bug control and resistance of bed bug populations to a broad spectrum of active ingredients. Veterinary drugs are commonly used to control endo- and ectoparasites in animals. In this study, we evaluated the effects of two common veterinary drugs on bed bugs by treating the host with systemic antiparasitic drugs. Methods We conducted dose–response studies of ivermectin and fluralaner against several bed bug strains using a membrane feeding system. Also, different doses of these drugs were given to chickens and two delivery methods (topical treatment and ingestion) were used to evaluate the efficacy of ivermectin and fluralaner on bed bug mortality. Results Using an artificial feeding system, both ivermectin and fluralaner caused high mortality in insecticide-susceptible bed bugs, and fluralaner was found to be effective on pyrethroid- and fipronil-resistant bed bugs. Ivermectin was ineffective in chickens either by the topical treatment or ingestion, whereas bed bugs that fed on chickens which had ingested fluralaner suffered high mortality when feeding on these chickens for up to 28 days post treatment. Conclusions These findings suggest that systemic ectoparasitic drugs have great potential for practical use to control bed bug infestations in poultry farms. These findings also demonstrate the efficacy of fluralaner (and potentially other isoxazolines) as a potent new active ingredient for bed bug control. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

et al. 2022

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“…Insecticides, such as pyrethrins and pyrethroid, are frequently used but decreasing in effectiveness due to resistance. Ivermectin and moxidectin are antiparasitic drugs that have been shown to kill bed bugs that consume blood meals containing these drugs in the laboratory [59][60][61]. A recent study involved bed bugs feeding on human blood after subjects were given oral ivermectin and demonstrated significant reductions in the population size and number of eggs laid [62 & ].…”

Section: Update On Bed Bugsmentioning

confidence: 99%

Common pediatric infestations: update on diagnosis and treatment of scabies, head lice, and bed bugs

Ogbuefi

Kenner‐Bell

2021

Current Opinion in Pediatrics

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Purpose of the review This review will update pediatric providers on the recent data regarding the epidemiology, diagnosis, and treatment of common skin infestations affecting children and adolescents. Recent findings Standard superficial skin biopsy for scabies and the vacuum method for head lice can increase diagnostic accuracy and efficiency. There is growing resistance to some of the traditional treatments for scabies and head lice, and progress has been made in finding newer and potentially more effective treatments, such as oral moxidectin for scabies and abametapir for head lice. Recent studies have established the safety of traditional treatments, such as permethrin and oral ivermectin in infants and small children. Summary Permethrin and ivermectin are both considered safe and effective for children and adolescents with scabies. Permethrin is generally considered safe in infants less than two months of age. Proper application of permethrin is critical, and providers should emphasize proper application technique. Treatment of head lice should only be initiated with active infestations. Resistance to permethrin continues to increase and other options are now available, including an over-the-counter topical ivermectin formulation. Identification and eradication of bed bug infestations are crucial in preventing bedbug bites.

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Ivermectin and Moxidectin Can Incapacitate Different Strains of the Common Bed Bug Cimex lectularius L.: A Study

Cited by 2 publications

References 20 publications

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

Common pediatric infestations: update on diagnosis and treatment of scabies, head lice, and bed bugs

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