Ivermectin pharmacokinetics in horses organism after the application of Equiverm antiparasitic paste

The purpose of the research is to study the effect of the new antiparasitic 2.0% Equiverm in high doses on the clinical state of horses.Materials and methods. The experiment was conducted on 15 two-year-old crossbred horses weighing up to 300 kg spontaneously infected with Strongylata. To determine the effect of the antiparasitic paste on the horses, three groups of five horses each were formed. The first group of the horses was administered 2.0% Equiverm at a therapeutic dose; the second, at a three-fold increased dose, and the third, at a five-fold increased dose (0.2; 0.6 and 1.0 mg/kg for the active substance (AS), and 1.0; 3.0 and 5.0 mL per 100 kg of body weight for the drug). The horses’ clinical state was studied using standard methods. Blood samples for the study were taken from the jugular vein before the drug on the first, third and seventh days. The results obtained were statistically processed using the computer tool Microsoft Excel 2007.Results and discussion. It was found that the antiparasitic paste 2.0% Equiverm had no negative effect on clinical, hematological or biochemical parameters after a single oral administration at a therapeutic, three- and five-fold increased dose (0.2; 0.6 and 1.0 mg/kg for the AS, and 1.0; 3.0 and 5.0 mL per 100 kg of the body weight for the drug).

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Effects of 2.0% Equiverm in high doses on the clinical state of the horses’ organism

Musaev

Emelyanova

Belova

2022

Ross. parazitol. ž..

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Methodology for the use of Equiverm-2.0% against equine parasite infections

Musaev

Emelyanova

2023

Ross. parazitol. ž..

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The purpose of the research is to develop a methodology for Equiverm-2.0% paste used against equine parasite infections.The methodology provides a brief description of Equiverm-2.0%, mechanism of its action, pharmaco-toxicological properties, application, slaughter terms, and personal safety measures. Equiverm-2.0% antiparasitic paste consists of the active ingredient, ivermectin, and excipients; it is a light cream-coloured paste with a slight pine odor and sweetish taste. The drug is administered orally at a therapeutic dose of 0.2 mg/kg for the active substance. One gram of paste is equal to 1 mL in volume with 20 mg of ivermectin. Ivermectin in Equiverm-2.0% paste is in a dissolved form, and forms an intermolecular complex. The antiparasitic paste is packaged in disposable polyethylene syringe dispensers of 5 or 10 mL, respectively, 4 to 8 g each, per treated horse weighing 400-800 kg. When administered orally, the paste spreads in the oral cavity and the animal eats it with pleasure due to its sweetish taste. The drug is recommended for registration in the Russian Federation.

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Testing of the supramolecular complex of ivermectin Aniverm-2.0% against parasitosis on various types of livestock animals

Musaev,

Zashchepkina,

Belova

et al. 2024

Ross. parazitol. ž..

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The purpose of the research is to obtain and test a complex drug Aniverm-2.0% based on the ivermectin substance by free feeding in a mixture with concentrated feed against parasitosis of cattle, sheep, and horses.Materials and methods. Aniverm-2.0% obtained by mechanochemical technology was tested on a farm in the Shatoy Region, the Chechen Republic, on 900 sheep, 180 cattle and 156 horses in March-April 2023. To determine the infection rate, coproovoscopic examinations were conducted on 80 samples from sheep, 20 samples from young cattle and 30 samples from horses using the Fulleborn’s flotation method with a saturated sodium chloride solution. Sheep were dewormed using a group method. The drug was mixed with feed per 0.3 mg/kg for the AS or 60 mg for the drug per animal. The young cattle were kept by tie-up housing and therefore they were given Aniverm-2.0% once at a dose of 0.2 mg/kg for the AS individually in a mixture with feed. The horses were given the drug in a group method at a dose of 0.2 mg/kg for the AS or 1.5 mg/kg for the drug. Fecal samples from all animals were examined before and 2 weeks after the drug.Results and discussion. A 100% rate of infection of the sheep by gastrointestinal nematodes (Strongylata, Nematodirus spp., Trichocephalus spp.) was determined with an average number of eggs 633.3 in 1 g of feces. In 20 fecal samples from the young cattle, 16 were found to have Strongylata eggs (prevalence = 80.0%) with 222.2–280.5 specimens of Strongylata eggs found in 1 g of feces. Strongylata eggs were found in all 30 examined fecal samples from the horses, on average, 253.3 specimens/g of feces (100%). At 2 weeks after treatment, nematode eggs were found in three out of 80 examined fecal samples from the sheep, which can be explained that the sheep did not eat the appropriate dose of the drug. The drug efficacy was determined to be 99.7%. One hundred percent efficacy of the drug was obtained on young cattle and horses.

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Ivermectin pharmacokinetics in horses organism after the application of Equiverm antiparasitic paste

Cited by 3 publications

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Effects of 2.0% Equiverm in high doses on the clinical state of the horses’ organism

Effects of 2.0% Equiverm in high doses on the clinical state of the horses’ organism

Methodology for the use of Equiverm-2.0% against equine parasite infections

Testing of the supramolecular complex of ivermectin Aniverm-2.0% against parasitosis on various types of livestock animals

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