Ivermectin Treatment of Bancroftian Filariasis in Recife, Brazil

Coutinho, Amaury; Dreyer, Gerusa; Medeiros, Zulma; Lopes, Edmundo Pessoa; Machado, Gabriela; Galdino, Eliane; Rizzo, José Ângelo; Andrade, Luiz Dias de; Rocha, Abraham; Moura, Izolda

doi:10.4269/ajtmh.1994.50.339

Cited by 30 publications

(22 citation statements)

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“…The peak number of events occurred slightly earlier in the DEC group, paralleling earlier peaks in both serum IL-5 and CD69 expression post-DEC. These findings are consistent with the tendency toward more rapid and complete microfilarial killing following single-dose DEC therapy and are supported by the data from prior single drug studies in loiasis and other filarial infections in which the peak of AEs following DEC is typically within 8 hours [15,16] compared with 24-36 hours post-IVM [17][18][19][20][21] (Supplementary Table 3).…”

Section: Discussionsupporting

confidence: 76%

Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection

Herrick

Legrand

Gounoue

et al. 2017

Clinical Infectious Diseases

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Background. Severe adverse reactions have been observed in individuals withLoa loa infection treated with either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in Africa. In this study, posttreatment clinical and immunologic reactions were compared following single-dose therapy with DEC or IVM to assess whether these reactions have the same underlying pathophysiology.Methods. Twelve patients with loiasis and microfilarial counts <2000 mf/mL were randomized to receive single-dose DEC (8 mg/kg) or IVM (200 µg/kg). Clinical and laboratory assessments were performed at 4, 8, 24, 48, and 72 hours and 5, 7, 9, and 14 days posttreatment.Results. Posttreatment adverse events were similar following DEC or IVM, but peaked earlier in subjects who received DEC, consistent with a trend toward more rapid and complete microfilarial clearance in the DEC group. After a transient rise (post-IVM) or fall (post-DEC) in the first 24 hours posttreatment, the eosinophil count rose significantly in both groups, peaking at day 5 in the DEC group and day 9 in the IVM group. Serum interleukin 5 levels and eosinophil activation, as assessed by surface expression of CD69 and serum levels of eosinophil granule proteins, were increased posttreatment in both groups.Conclusions. Despite differences in eosinophil and lymphocyte counts during the first 24 hours posttreatment, the overall pattern of hematologic and immunologic changes suggest that posttreatment reactions following DEC and IVM share a common pathophysiology.Clinical Trials Registration. NCT01593722.

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Section: Discussionsupporting

confidence: 76%

Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection

Herrick

Legrand

Gounoue

et al. 2017

Clinical Infectious Diseases

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“…carbamazine for treatment of bancroftian filariasis conducted in Recife. Details of these drug trials have Microfilarial periodicity been reported previously (Coutinho et al 1994, Dreyer e t a / . 19941995).…”

Section: Resultsmentioning

confidence: 99%

“…In a recent new survey of 272 persons, 24 (8.8%) were found to be microfilaraemic on the basis of 6oyl night blood films, 3 I (11.4%) by filtration of I ml venous blood and 37 (13.6%) by filtration of 5 ml venous blood. parative efficacy of ivermectin (IVM) and diethylcarbamazine (DEC) for treatment of bancroftian filariasis indicate that IVM clears mf from the systemic circulation more rapidly than DEC during the first month after treatment, whereas DEC is more effective in preventing microfilarial recrudescence than IVM 1-1 years after treatment (Coutinho et a/. 1994, Dreyer et al 1994.…”

Section: Identification Of Low Density Microfilaraemia Carriers In Grmentioning

confidence: 99%

Studies on the periodicity and intravascular distribution of Wuchereria bancrofti microfilariae in paired samples of capillary and venous blood from Recife, Brazil

Dreyer

Pimentael

Medeiros

et al. 1996

Tropical Med Int Health

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We examined the periodicity and intravascular distribution of Wuchereria bancrofti microfilariae (rnf) and determined the effect of these parasite properties on the accuracy of blood filming and filtration methods for diagnosis of bancroftian filariasis in the endemic area of Recife, Brazil. Microfilariae in both venous and capillary blood exhibited a nocturnal periodicity pattern with a relatively high amplitude. Overall, capillary blood contained -1.25 times the number of rnf present at the same time in the same volume of venous blood. However, the ratio of rnf present in capillary and venous blood varied over a z4-hour period, so that the fewest mf were present in the capillary bed of the skin at the time when biting activity of the local Culex vector is the lowest. Twenty or 6 0 p1 blood films did not reliably detect carriers with fewer than IOO or 60 rnf/ml venous blood, respectively, and were thus inadequate for the identification of low density rnf carriers. In contrast, all carriers with > I mW2o or 60 pl blood smear at night could be identified during daytime hours by filtration of I ml venous blood keywords Wuchereria bancrofti, periodicity, distribution, capillary blood, venous blood, thick smear. filtration

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“…The candidate drug ivermectin, though very effective against microfilariae of different filaids in single or divided semi-annual or annual dose regimens (Kumaraswami et al 1988;Coutinho et al 1994), is ineffective against adult filariae (Dreyer et al 1995(Dreyer et al , 1996. Nevertheless, due to its rapid clearance of microfilariae from blood, ivermectin may cause an equal, if not more severe, reaction than DEC (Ottesen 1987;Richards et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Antifilarial activity of a synthetic marine alkaloid, aplysinopsin (CDRI Compound 92/138)

Singh

Bhatnagar

Fatma

et al. 1997

Tropical Med Int Health

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SummaryCDRI Compound 92/138, a synthetic analogue of aplysinopsin, was evaluated in experimental filarial infections, Litomosoides carinii in cotton rats (Sigmodon hispidus) and Acanthocheilonema viteae in Mastomys coucha. The compound killed 63.8 and 90% of adult L. carinii and A. viteae at doses of 30 and 50 mg/kg (i.p.) respectively given for 5 days. By the oral route, at 100 mg/kg for 5 days the compound caused 50.9 and 57% mortality of adult L. carinii and A. viteae, respectively. At 200 mg/kg administered orally on days 0, 10 and 25 post-infection, it reduced establishment of adult A. viteae by 68.5%. We also found 43.7 and 37.8% effect in vivo respectively on L3 and L4 stages of A. viteae at a single dose of 250 mg/kg, p.o. The compound was active in vitro at 100 g/ml concentration and caused a significant decline in MTT reduction and 14 C-glucose uptake by adult filariids. Thus synthetic marine aplysinopsin could provide a new pharmacophore for the development of antifilarial agents.

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Ivermectin Treatment of Bancroftian Filariasis in Recife, Brazil

Cited by 30 publications

References 0 publications

Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection

Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection

Studies on the periodicity and intravascular distribution of Wuchereria bancrofti microfilariae in paired samples of capillary and venous blood from Recife, Brazil

Antifilarial activity of a synthetic marine alkaloid, aplysinopsin (CDRI Compound 92/138)

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