IVF: Induction of ovulation in poor responders

Modified Natural Cycle Using GnRH Antagonist Can Be an Optional Treatment in Poor Responders Undergoing IVF

“…Various studies have attempted to determine the most efficient protocol for patients with poor ovarian response, such as increasing the dose of gonadotrophins (13,14), the use of recombinant FSH (15), supplementation of growth hormone (16), and altered time and dose of administration of GnRH agonists (7,17). No convincing advantage for one protocol over another has been established to date (18).…”

Role of gonadotropin-releasing hormone antagonists in poor responders

“…Although two reports in the late 1980s suggested that high doses of gonadotropins (Ͼ300 IU per day) in poor responders enhanced follicular development (8) and reduced cycle cancellation rates (9), the preponderance of evidence does not support this approach (10 -13). Thus, although virtually all poor-responder protocols utilize high gonadotropin doses (typically 300 -450 IU per day), other tactics are usually also employed.…”

Different ovarian stimulation protocols for women with diminished ovarian reserve

“…Some researchers have reported improved outcome [55,56]. According to most authors, the common initial dose for poor responders is at least 300 IU/day.…”