IVF Lite - A new strategy for managing poor ovarian responders

Gandhi, Goral; Allahbadia, Gautam N.; Kagalwala, Sakina; Khatoon, Aaisha; Hinduja, Ritu; Allahbadia, Akanksha

doi:10.4103/2348-2907.127087

Cited by 12 publications

(7 citation statements)

References 23 publications

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“…Also, vitrification of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared to fresh and slow-freezing procedures, respectively [18]. This is the global trend now, and especially for older women, poor responders and now even for hyper-responders, a deferred or remote ET is preferred [3,4,11,12].…”

Section: Discussionmentioning

confidence: 98%

“…Till a few years ago, apart from oocyte donation, there was no known intervention to improve the pregnancy outcome of older patients. Today, with the widespread use of the IVF Lite protocol [2][3][4] and the advent of next-generation sequencing (NGS) technology to screen embryos [5,6], we have pregnancy rates that have almost doubled in older women from a decade back.…”

Section: Introductionmentioning

confidence: 99%

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Getting Older Women Pregnant: Contemporary Thoughts

Allahbadia

2015

J Obstet Gynecol India

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For women of advanced age with abnormally increased FSH levels, standardized hormonal stimulation often represents a cost-intensive procedure with a low success rate. It is well established now that with mild ovarian stimulation, there is a greater percentage of goodquality eggs (although a smaller number) than with higherdose conventional stimulation. Mild stimulation protocols reduce the mean number of days of stimulation, the total amount of gonadotropins used and the mean number of oocytes retrieved. The proportion of high-quality and euploid embryos seems to be higher compared with conventional stimulation protocols, and the pregnancy rate per embryo transfer is comparable. Moreover, the reduced costs, the better tolerability for patients and the less time needed to complete an IVF cycle make mild approaches clinically and cost-effective over a given period of time. The low number of embryos available for transfer poses a great challenge in the management of older women going in for IVF. A potential management of these older women is to create a sufficient pool of embryos by accumulating 123 vitrified good-grade embryos over several minimal stimulation and natural cycles. At the end of the accumulation process, these embryos can be subjected to a preimplantation genetic screening using next-generation sequencing and then the pool would have only chromosomal normal embryos with maximal chances of implantation. This would potentially make the chances of success for older women similar to normal responders. This management, however, is unthinkable without an outstanding vitrification program. The option of accumulating embryos has become a promising reality with the advent of vitrification technologies.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Getting Older Women Pregnant: Contemporary Thoughts

Allahbadia

2015

J Obstet Gynecol India

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“…Natural cycle [18], modified natural cycle [19], and IVF Lite [20] are different protocols, which provide some advantages compared to conventional stimulation: lower medication cost, less injections, less invasive, low risk of ovarian hyperstimulation, and multiple pregnancy [18][19][20]. Their main drawback is high cancelation rate due to premature ovulation and lack of egg recovery at the retrieval.…”

Section: Discussionmentioning

confidence: 99%

“…Their main drawback is high cancelation rate due to premature ovulation and lack of egg recovery at the retrieval. When an embryo transfer can be performed, the cumulative pregnancy rate is similar to the results in conventional stimulation [18][19][20]. These protocols do not presently provide any advantage in terms of results for woman with normal ovarian reserve; however, they must be considered as a very good therapeutic alternative in poor responders.…”

Section: Discussionmentioning

confidence: 99%

The Ideal Stimulation Protocol: Is There One?

Allahbadia

2015

J Obstet Gynecol India

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“…Extending the embryo culture program and transferring a blastocyst on day 5 increased implantation rates to 32 % in comparison to day 3 transfer (23 %) with a [ 20 ] signifi cant increase in pregnancy rates in addition to a signifi cant decrease in the number of embryos transferred [ 38 ].…”

Section: Vitrifi Cation Of Human Zygotes and Cleaved Embryosmentioning

confidence: 99%

Vitrification of Day 2–3 Human Embryos Using Various Methods

Dalvit

2014

Vitrification in Assisted Reproduction

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IVF Lite - A new strategy for managing poor ovarian responders

Cited by 12 publications

References 23 publications

Getting Older Women Pregnant: Contemporary Thoughts

Getting Older Women Pregnant: Contemporary Thoughts

The Ideal Stimulation Protocol: Is There One?

Vitrification of Day 2–3 Human Embryos Using Various Methods

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