Substituted amide and dinitroaniline herbicides are used to selectively control annual grasses and certain broadleaf weeds in soybean (Glycine max (L.) Merr.]. Often, additional herbicide must be applied to COI!-trol other broadleaf weed species. The objective of this study was to determine if combinations of selected soil-applied herbicides could be used to control or suppress the growth in soybean of weeds that cannot be controlled with currently available herbicides. Field trials were conducted in 1982 and 1983 to evaluate the effects of two different application methods of trifluralin [2acetamide] combinations for controlling broadleaf weeds, including morningglory (Ipomoea spp.) and jimsonweed (Datura stramonium L.), in soybean. No significant differences in the control of broadleaf weeds were found between a sequential application and a tank-mix application of the two herbicides applied as a shallow incorporation. Both herbicide combinations provided good to excellent control of morningglory, and fair to good control of jimsonweed. The control of three Ipomoea species was not significantly different when combinations included either substituted amide. Greenhouse sand culture studies showed significant interaction effects of trifluralin plus alachlor combinations on the growth inhibition of soybean, hemp sesbania (Sesbania exaltata (Raf.) Rydb. ex A. W. Hill], morningglory, jimsonweed, velvetleaf (Abutilon theophrasti Medik), and sicklepod (Cassia obtusifolia L.). Soybean was much less sensitive to the herbicide interaction effects than were broadleaf weeds.