Ixeris sonchifolia: a review of its traditional uses, chemical constituents, pharmacology and modern applications

Li, Kunwei; Liang, Yi-Yu; Xie, Shimin; Niu, Feng-Jv; Guo, Ling-yan; Liu, Zi-Hao; Chang-zheng, Zhou; Wang, Lizhu

doi:10.1016/j.biopha.2020.109869

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…It is native to Europe and Central Asia, and is now mainly distributed in China, Japan, and Vietnam [1]. It is widely used in folk medicine because of its functions of heat-clearing, detoxification, stopping pain, cooling blood, and anti-inflammation [2]. It was first recorded in Shennong's Classic of Materia Medica (200-300 A.D., Han Dynasty) that Ixeris polycephala was used as a medicine.…”

Section: Introductionmentioning

confidence: 99%

“…All parts of Ixeris polycephala (Figure 1), including the roots, stems, leaves, and flowers, have been used as traditional Chinese medicines for thousands of years [3]. Recently, phytochemical studies showed that flavonoids, triterpenoids, sesquiterpenoids, organic acids, and phenylpropanoids are the main active components responsible for their beneficial efficacies [2]. These compounds have been shown to have a wide range of biological and pharmacological effects, such as anti-tumor [4], protecting the cardiocerebral vascular system [5], and liver protection [6].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Major Flavonoids among Parts of Lactuca indica during Different Growth Periods

Hao

Jia

et al. 2021

Molecules

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L. indica L. cv. Mengzao, a medicinal plant of the Ixeris genus, is rich in flavonoids. In order to thoroughly analyze the the distribution and dynamic change of major flavonoids in its various parts from different growth periods, the flavonoids extracted from L. indica L. cv. Mengzao were identified and quantitatively analyzed by ultra-high-performance liquid chromatography mass spectrometer (LC-MS/MS). Results indicated that 15 flavonoids were identified from L. indica L. cv. Mengzao, and rutin, luteolin, luteolin-7-O-glucoside, kaempferol, quercetin, and apigenin are the major flavonoids in L. indica L. cv. Mengzao. In general, the total flavonoids’ content in different parts of L. indica L. cv. Mengzao followed the order flowers > leaves > stems > roots. Flowers and leaves are the main harvesting parts of L. indica L. cv. Mengzao, and the flowering period is the most suitable harvesting period. This study provides valuable information for the development and utilization of L. indica L. cv. Mengzao and determined the best part to harvest and the optimal time for harvesting.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Major Flavonoids among Parts of Lactuca indica during Different Growth Periods

Hao

Jia

et al. 2021

Molecules

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“…Chemical fingerprinting is an analytical method for chemical profiling to identify authenticity, distinguish the origin, and evaluate the quality of herbal medicines and inter-related preparations (Li et al, 2020).…”

Section: Fingerprint Analysis and Metabolomics Approachmentioning

confidence: 99%

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

et al. 2021

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Sea buckthorn (Hippophae rhamnoides L., SBT) is being used as a folk medicine for their diverse medicinal properties. Flavonoids are generally considered as the main bioactive and characteristic ingredients in SBT. This review was conducted using a comprehensive literature search on the chemical components, quality control, pharmacokinetics of flavonoids from SBT (FSBT). Particularly, we highlighted the therapeutic potential in metabolic diseases and clinical applications of FSBT. More than 95 flavonoids have been identified from SBT. Although the oral bioavailability of FSBT was relatively low, FSBT displays significant effect on the regulation of metabolism to ameliorate metabolic disorders and their complications. There is a heightened need to explore the bioactive compounds in SBT and mechanism(s) of action of FSBT in order to fully understand the pathways of their activities. Practical applicationsFor years, due to the increasing emergence of metabolic syndrome and diverse functions of FSBT in regulating metabolism, they can be efficiently utilized for human health and have an urgent need to become a hotspot for research. This review will broaden the understanding of FSBT, providing some directions for further development and expanding the therapeutic applications of FSBT.

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“…However, the reported findings in the literature are obtained from retrospective studies, and thus there might be a component of bias in reporting the efficacy. The bias could arise from the subjectivity of the clinician, experimental methods, sample size, and the classification of disease, which are parameters difficult to control in clinical studies (Li et al 2020(Li et al , 2021.…”

Section: Clinical Studiesmentioning

confidence: 99%

Antiviral Properties of Baicalin: a Concise Review

Liang

Cheng

et al. 2021

Rev. Bras. Farmacogn.

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Baicalin is one of the bioactive flavonoid glycosides isolated from the dried root of Scutellaria baicalensis Georgi, Lamiaceae, with antiviral properties. In recent years, the antiviral activity of baicalin has been widely investigated to explore its molecular mechanism of action. In this mini-review, the molecular mechanisms of action of baicalin as an antiviral agent are evaluated, which included three categories: the inhibition or stimulation of JAK/STAT, TLRs, and NF-κB pathways; up or down modulation of the expression levels of IFN, IL, SOCS1/3, PKR protein, Mx1 protein, and AP-1 protein; and inhibition of cell apoptosis caused by virus infection. In addition, clinical studies of baicalin are also discussed. This literature search suggested that baicalin can serve as a potential candidate for the development of a novel broad-spectrum antiviral drug.

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Ixeris sonchifolia: a review of its traditional uses, chemical constituents, pharmacology and modern applications

Cited by 15 publications

References 31 publications

Comparative Analysis of Major Flavonoids among Parts of Lactuca indica during Different Growth Periods

Comparative Analysis of Major Flavonoids among Parts of Lactuca indica during Different Growth Periods

Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases

Antiviral Properties of Baicalin: a Concise Review

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