Izkhar [Cymbopogon martinii (Roxb.)] Wats.: An evidence-based review on its phytochemical aspect and hepatoprotective traditional use in Unani medicine

Ara, Shabnam Anjum; Borjali, Ahmad; Fazil, Mohammad; Akhlaq, Shaheen; Akram, Usama; Haque, Merajul; Khan, Asim Ali

doi:10.1016/j.hermed.2022.100576

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…The herbal drugs have an added advantage as they provide prevention as well as treatment of any disease. Their reliance and acceptance lies in the fact that their source of origin is nature based, and they are safe, efficacious and cost effective [1]. The Unani system of Medicine (USM), at present is popular in many countries of Arab and Asia, and is also accepted by World Health Organization as an alternative system of medicine [2,3].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Traditional Uses and Biological Activities of Irsa (Iris Ensata Thunb.): A Multi Potent Unani Medicine

2023

IJBPAS

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The last few decades have observed a change in perspective regarding therapeutic approach to medicine; as a result the demand of herbal drugs has seen an exponential increase worldwide. More and more research is being performed to appraise the safety and efficacy of such drugs, in order to achieve comprehensive cure for ailments. Irsa, the dried root of Iris ensata Thunb. of family Iridaceae is used since ancient times in Unani system of medicine for various illnesses. Significant evaluation was carried out of Unani manuscripts/traditional/scientific literature, present and previous research/review papers and databases such as Wiley Online Library, Science-Direct, etc to extract maximum information of Irsa. On exploration of its phytochemistry, flavonoids, isoflavonoids, glycosides, phenolics, tannins, and other components were found to be potential bio-compounds and active metabolites responsible for its multipotent activities, specifically its bronchodilator, concoctive and deobstruent actions. The oil extracted from the drug is also found to be equally beneficial. This, review paper aims to highlight the comprehensive aspect of Irsa, keeping in view of its temperament, medicinal properties and therapeutic use; to signify its efficacy in the treatment of wide

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Section: Introductionmentioning

confidence: 99%

Phytochemistry, Traditional Uses and Biological Activities of Irsa (Iris Ensata Thunb.): A Multi Potent Unani Medicine

2023

IJBPAS

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“…The indigenous herbal approach plays an essential part in the healthcare system and has become increasingly popular in recent decades due to its natural composition, fewer side effects, and higher efficacy than synthetic drugs. Herbal medicine has the virtue of being both preventative and curative and diagnoses and treats illnesses [1]. Since phytoconstituents such as glycosides, saponins, flavonoids, steroids, tannins, alkaloids, terpenes, and others have been shown to have pharmacological effects, medicinal products have been recognised as a significant source for creating novel pharmaceutical molecules.…”

Section: Introductionmentioning

confidence: 99%

CLOVE/QURANFUL (Syzygium aromaticum L.): A REVIEW ON ITS POTENTIAL BENEFITS IN UNANI MEDICINE, BIOACTIVITIES AND CURRENT SCIENTIFIC APPLICATIONS

Ara¹,

Akhlaq²,

Haque³

et al. 2022

IJUM

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Background: Herbal drugs have been shown to be a valuable source of new pharmaceutical molecules that have been utilised to treat serious disorders. Clove (Syzygium aromaticumL.) is a plant-derived drug with a long history of usage in Unani medicine due to its numerous pharmacological benefits attributable to its phytoconstituents. Aims and objectives: The basic aim of this article is to present a comprehensive report on the potential benefits of clove as described in the Unani system of medicine as well as present an analysis of contemporary scientific researches in order to explore the prospects for its application. Materials and methods:Classical data were collected from the manuscripts of Unani medicine like Al Qanoon Fit Tib, Khazain al-Advia, Makhzan al-Advia, Muheet-i-Azam, Al-Jami li Mufradat al- Advia wa'l Aghziya, etc. An online search was performed in Pub Med, Scopus, Wiley Online Library and Google Scholar to elucidate the various pharmacological activities of clove. Results: The potential of clove shown by its chemical composition, therapeutic use and bioactivities revealed its antibacterial, anti-fungal, anti-viral, anti-oxidant, anti-inflammatory, anticancer, hepatoprotective and nephroprotective effects. Sesquiterpenes, monoterpenes, hydrocarbon, and phenolic compounds, are found in abundance in S. aromaticu, with eugenyl acetate, eugenol, and β-caryophyllene being the mostimportant phytochemicals reportedin clove oil. Several in vitro and in vivo studies have demonstrated its multiple bioactivities, exhibiting its effect on diseases including halitosis, odontalgia, thyroidcancer, rheumatoidarthritis, nephrotoxicity, and vaginal candidiasis, among others. Conclusion: The several studies evaluated in this article support clove's traditional use in Unani medicine, indicating its usefulness for a variety of ailments. Future research should focus on developing new clove derivative-based formulations

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An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota

Akhlaq,

Ara,

Itrat

et al. 2024

CDT

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Background and Aim: Diabetes mellitus is a chronic, multi-factorial metabolic disorder and also an important public health issue that requires multi-dimensional therapeutic strategies for effective control. Unani herbs have long been used to effectively mitigate diabetes through various mechanisms. In recent years, it has been speculated that the alteration of gut microbiome ecology is potentially one of the important mechanisms through which the Unani drugs exert hypoglycemic action. This review aims at the trans-disciplinary interpretation of the holistic concepts of the Unani system of medicine and the molecular insights of contemporary medicine for novel strategies for diabetes management. Methodology: We searched scientific databases such as PubMed, Google Scholar, and Science-Direct, etc. Unani classical texts (Urdu, Arabic, and Persian), and medical books, for diabetic control with Unani medicine through the gut microbiome. Results: Unani medicine defines, diabetes as a urinary system disorder disrupting the transformational faculty (Quwwat Mughayyira) in the gastrointestinal tract. The Unani system and contemporary biomedicine use different epistemology and ontology for describing diabetes through gutderived factors in whole-body glucose homeostasis. Unani Pharmaceutics have reported in clinical and preclinical (in vitro/ in vivo) trials in improving diabetes by altering gut microbiota composition, microvascular dysfunction, and inflammation. However, the preventive plan is the preservance of six essential factors (Asbāb Sitta Ḍarūriyya) as a lifestyle plan. Conclusion: This is the first study on the integrative strategy about the hypoglycemic effects of Unani herbs that could serve as a prerogative novel approach for cost-effective, holistic, rationalistic, and multi-targeted diabetes management.

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Izkhar [Cymbopogon martinii (Roxb.)] Wats.: An evidence-based review on its phytochemical aspect and hepatoprotective traditional use in Unani medicine

Cited by 3 publications

References 15 publications

Phytochemistry, Traditional Uses and Biological Activities of Irsa (Iris Ensata Thunb.): A Multi Potent Unani Medicine

Phytochemistry, Traditional Uses and Biological Activities of Irsa (Iris Ensata Thunb.): A Multi Potent Unani Medicine

CLOVE/QURANFUL (Syzygium aromaticum L.): A REVIEW ON ITS POTENTIAL BENEFITS IN UNANI MEDICINE, BIOACTIVITIES AND CURRENT SCIENTIFIC APPLICATIONS

An Exploratory Review on the Hypoglycemic Action of Unani Anti-diabetic Drugs via Possible Modulation of Gut Microbiota

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