J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery

Hollow Manganese Dioxide Nanoparticles for Drug Delivery and Imaging

“…Furthermore, in contrast to other inorganic nanomaterials that are not biodegradable, the water-soluble Mn 2+ generated by the decomposition of MnO 2 nanomaterials can be rapidly eliminated through renal metabolism without posing a threat to human health. − Second, H-MnO 2 , with its mesoporous structure, has a large cavity and has proven to be a successful drug delivery system. It can be loaded with large amounts of therapeutic agents, and its release can be accurately controlled by adjusting the coating or shell structure in response to the tumor microenvironment. − …”

Supramolecular Aggregation of Carbon Nanodots

“…Supramolecular chemistry, which refers to multiple molecules that are combined by intermolecular interaction to form complex and organized aggregates, have been constructed to understand the variants between the molecular monomer or aggregates. − For example, the dipoles of molecules will repel each other and hold in the high-energy state in the J-aggregation, leading to the red shift in the absorption band and a nearly resonant fluorescence with a narrow band. , In contrast, the dipoles of molecules will attract each other and are in the low-energy state in the H-aggregation, resulting in the blue shift in absorption and low or no fluorescence with respect to their monomers. , With the supramolecular aggregation, the multiple molecular aggregates can alter their basic and recognizable spectral characteristics, endowing them with more applications. Recently, the supramolecular aggregation has extended the domains of coherently coupled molecular transition dipoles and provides the new concept to understand the photophysical properties of constructed molecules, revealing the new block to advocate the aggregation as archetype concept for an emerging system property on the molecular or nanoscale level. − To date, various supramolecular systems with molecules, polymers, or nanoparticles have been developed to build the special structure or regulate the physicochemical properties, enabling their novel characteristics in chemical analysis, optoelectronic devices, or biomedicines. Therefore, it is still significant to develop more nanomaterials as blocks to establish supramolecular systems.…”