I would also like to extend my gratitude to Drs. Xinwei Deng, Klaus Hinkelmann, and Brad Jones, who were gracious enough to serve on my committee. Their advice and suggestions are greatly appreciated and I hope to work with them again in the future. Finally, I want to thank my family, especially my father, Wade, brother, Robert, and sister, Amy, and beloved partner, Sarah, who provided constant support during many personal challenges, including my mother's unexpected passing. I would like to dedicate this dissertation to my mother, Delores Tiller Stallings, who would have been immensely proud to see it completed. iii List of Tables 3.1 Weights assigned by W Hw in Example 3.2.1 to pairwise comparisons for treatments between and within treatment groups V 1 and V 2 with w 0 = 20.. .. . 3.2 Replication proportions for treatments of a given heft for A-optimal approximate CRD with respect to estimation of all non-normalized BP effects.. .. 3.3 A-optimal CRDs for estimation of all non-normalized BP effects for m = 3 factors. The last row indicates whether the design is a BA of strength 3.. . 3.4 A-optimal CRDs for estimation of all normalized BP effects for m = 3 factors. The last row indicates whether the design is a BA of strength 3.. .. .. . .