We estimate, for the first time, the Υ and η b mass shifts in symmetric nuclear matter. The estimate for the Υ is made using an SU(5) effective Lagrangian, studying the BB, BB * , and B * B * meson loop contributions for the self-energy. As a result, we include only the BB meson loop contribution as our minimal prediction. As for the η b , we include only the BB * meson loop contribution in the self-energy to be consistent with the minimal prediction for the Υ mass shift. The in-medium masses of the B and B * mesons appearing in the self-energy loops are calculated by the quarkmeson coupling model. Form factors are used to regularize the loop integrals with a wide range of the cutoff mass values. A detailed analysis on the BB, BB * , and B * B * meson loop contributions for the Υ mass shift is made by comparing with the corresponding DD, DD * , and D * D * meson loop contributions for the J/Ψ mass shift. Based on the analysis for the Υ, our prediction for the η b mass shift is made on the same footing as that for the Υ, namely including only the BB * meson loop. The Υ mass shift is predicted to be -16 to -22 MeV at the symmetric nuclear matter saturation density with the cutoff mass values in the range 2000 -6000 MeV using the ΥBB coupling constant determined by the vector meson dominance model, while the η b mass shift is predicted to be -75 to -82 MeV with the SU(5) universal coupling constant determined by the ΥBB coupling constant and for the same range of the cutoff mass values.