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Abstract

Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. Appropriate analytical techniques for the characterization of SLN like Photon Correlation Spectroscopy (PCS), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers are also discussed.

Solid Lipid Nanoparticles: A Review

“…There are various methods of preparation of SLNof which commonly used preparation method is High pressure homogenization by hot homogenization [16,17].Various methods of preparation and purification of SLN are listed in Table 2.…”

“…Assessing particle size of SLN is important as it will affect the physical stability of formulation [7,17]. It can be done by following technique:…”

“…Zeta potential canbe used in planning particles with reduced RES uptake. Value ranging from -25 to +25is acceptable and it can be concluded that the particles have enough electrostatic potential [7,17]. Higher the value indicates repulsion forces dominating due to which particle aggregation will be less and formulation can have good stability.…”