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Abstract

Background: Thyroid disorders are very common in the general population and is second most common condition affecting the endocrine system after diabetes mellitus. Decreased production of thyroid hormone is the key feature of hypothyroidism. Aims and Objectives: To Study Sr. Fructosamine level, FPG and HbA1C level in the hypothyroid patients at tertiary health care centre. Methodology: This was a cross-sectional study carried out in the department of Biochemistry of a tertiary health care centre during the one year period i.e. March 2017 to March 2018 , in one year duration the diagnosed patients of Hypothyroidism (n=45) and Other eu-thyroid patients (n=45) were selected into the study after the written explained consent. All the patients undergone the investigations like FPG, HbA1C, Fructosamine biochemical tests carried out by standard biochemical procedures. All details of the patients like age, sex was noted. The statistical analysis was done by unaired t-test, and calculated by SPSP 19 version software. Result: In our study we have seen that the average age of the patients in both the groups was 49 ± 5.34 and 50± 4.57 (p >0.05, df=88, unpaired-t=1. 45) was comparable to each other. The Male: Female sex ratio was 2.33 and 3.44 was comparable to each other (X2=0.24, df=1,p>0.05).The parameters were significantly higher like ; FPG (mg/dl)-91.56±7.89 and 80.92 ±5.82 (t=7.28,df=88,p<0.0001); HbA1C-7.12± 3.45 and 5.34± 2.91 (t=9.83,df=88,p<0.0001); Fructosamine (μmol/L)-593.87±56.89 and 257.92±8.95 (t=5.73,df=88,p<0.001) in Hypothyroid group as compared to Euthyroid group respectively. Conclusion: It can be concluded from our study that FPG < HbA1C and Fructosamine were significantly higher in Hypothyroid group as compared to euthyroid group.