Jaboticaba berry: A comprehensive review on its polyphenol composition, health effects, metabolism, and the development of food products

Inada, Kim Ohanna Pimenta; Leite, Iris Batista; Martins, Ana Rosa Fonseca de Aguiar; Fialho, Eliane; Tomás-Barberán, Francisco A.; Perrone, Daniel; Monteiro, Mariana

doi:10.1016/j.foodres.2021.110518

Cited by 44 publications

(23 citation statements)

References 179 publications

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“…More severe cell damage can lead to greater LDH leakage in its supernatant and a higher degree of injury in the cell membrane [31]. CAT is an important antioxidant enzyme in the body, and a higher activity of CAT implies a stronger capacity to remove peroxides [32]. Svobodova et al [33] confirmed that flavonoid extraction from Silybum marianum seeds could reduce UVA stimulation-caused ROS and increase glutathione activity, thereby reducing MMP-1 and caspase levels.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Song

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effects and corresponding mechanisms of total flavonoids (TFL) from Lycium barbarum leaves on photoaged human dermal fibroblasts (HDFs). Methods. Crude TFL was extracted with 70% ethanol, and a Rutin standard curve was drawn using the sodium nitrite-aluminum nitrate-sodium hydroxide colorimetry method to calculate its yield and mass concentration. After that, the photoaging HDFs model was established by UVA combined with 8-MOP. CCK-8 was performed to assess the influence of TFL on the proliferation of HDFs and photoaging HDFs. β-galactosidase (SA-β-gal) staining and activity assays were performed to evaluate the activity of SA-β-gal and the rate of SA-β-gal-positive cells in HDFs cells. The level of skin ECM proteins and oxidative stress-related substances in HDFs cells of each group was determined by ELISA and biochemical detection, respectively. Apoptosis of HDFs in each group was assessed by flow cytometry. The expressions of MAPK signaling pathway-related proteins in HDFs were detected by western blot. Results. The yield rate of TFL extracted by 70% ethanol was 41.9%, and its purity rate was 34.6%. TFL at 25, 50, and 100 μg/mL was able to greatly promote the proliferation of HDFs. A photoaged HDFs model was successfully constructed by combining UVA irradiation at 9 J/cm2 and 8-MOP at 50 mg/L. TFL treatment could significantly inhibit apoptosis, SA-β-gal-positive cell staining rate, SA-β-gal activity, lactate dehydrogenase (LDH) leakage, and malondialdehyde (MDA) content in photoaged HDFs. Further, TFL increased the proliferative activity, superoxide dismutase (SOD) activity, catalase (CAT) activity, type I collagen (Col I), hydroxyproline (HYP), and hyaluronic acid (HA) level of photoaged HDFs in a dose-dependent manner. Additional experiments suggested that TFL played a protective role by downregulating MAPK signaling pathway activity in photoaged HDFs cells. Conclusion. TFL could inhibit oxidative stress and apoptosis, promote cell proliferation and the level of ECM-related component proteins, and participate in antiphotoaging in a concentration-dependent manner. The protective role of TFL in photoaged HDFs might be related to its inhibition of MAPK signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Song

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…contain cyanidin 3-rutinoside (29–218 mg/100 g), cyanidin 3-glucoside (31–108 mg/100 g) and peonidin 3-glucoside (4–10 mg/100 g) [ 60 ]. The most common anthocyanins in Brazilian jaboticaba fruit are the glucosides of cyanidin (123–433 mg/100 g dry weight) and delphinidin (23.5–81 mg/100 g dry weight) as well as the galactosides of cyanidin (418.35 mg/100 g dry weight) and delphinidin (61.57 mg/100 g dry weight) [ 61 ].…”

Section: Sources Of Anthocyaninsmentioning

confidence: 99%

“…Additional potential therapeutic benefits of blueberries, based mainly on animal or cell studies, have included actions on lung function, bone strength, vision and degenerative diseases [ 272 ]. Other less well-known fruits and cereals with potential for prevention or treatment of chronic diseases that contain similar amounts of anthocyanins include black chokeberries [ 273 ], Saskatoon berries [ 274 ], jaboticaba berries [ 61 ], black rice [ 275 ], and coloured wheat [ 276 ] as well as a wide range of tropical minor fruits [ 277 ]. These anthocyanins could be extracted using novel techniques.…”

Section: Further Roles For Anthocyanins In Societymentioning

confidence: 99%

Anthocyanins in Chronic Diseases: The Power of Purple

et al. 2022

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Anthocyanins are mainly purple-coloured phenolic compounds of plant origin that as secondary metabolites are important in plant survival. Understanding their health benefits in humans requires sourcing these unstable compounds in sufficient quantities at a reasonable cost, which has led to improved methods of extraction. Dark-coloured fruits, cereals and vegetables are current sources of these compounds. The range of potential sustainable sources is much larger and includes non-commercialised native plants from around the world and agri-waste containing anthocyanins. In the last 5 years, there have been significant advances in developing the therapeutic potential of anthocyanins in chronic human diseases. Anthocyanins exert their beneficial effects through improvements in gut microbiota, oxidative stress and inflammation, and modulation of neuropeptides such as insulin-like growth factor-1. Their health benefits in humans include reduced cognitive decline; protection of organs such as the liver, as well as the cardiovascular system, gastrointestinal tract and kidneys; improvements in bone health and obesity; and regulation of glucose and lipid metabolism. This review summarises some of the sources of anthocyanins and their mechanisms and benefits in the treatment of chronic human diseases.

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“…Polyphenols are a large class of compounds with strong radical scavenging, anti-inflammatory and many additional health promoting effects [ 89 ]. Fruits and vegetables such as elderberry, chokeberry, blackcurrant, artichoke and black bean have been long established as rich sources of polyphenols [ 90 ].…”

Section: Therapeutic Potential Of Microalgae In Sleep and Mood Regula...mentioning

confidence: 99%

“…The bioavailability of phytosterols is governed by their crystalline structure, degree of saturation, chain length, source, delivery route as well as ingested food matrix [ 89 ]. Marine algae are abundant in phytosterols, whereas fucosterol is produced by several microalgae.…”

Section: Bioavailability and Delivery Of Microalgae Extracts To The T...mentioning

confidence: 99%

Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges

2022

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Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review explores the relevance of microalgae bioactives as a sustainable source of valuable phytochemicals that can contribute positively to mood and sleep disorders. Microalgae species producing these compounds are also catalogued, thus creating a useful reference of the state of the art for further exploration of this proposed approach. While we highlight possibilities awaiting investigation, we also identify the associated issues, including minimum dose for therapeutic effect, bioavailability, possible interactions with conventional treatments and the ability to cross the blood brain barrier. We conclude that physical and biological functionalization of microalgae bioactives can have potential in overcoming some of these challenges.

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Jaboticaba berry: A comprehensive review on its polyphenol composition, health effects, metabolism, and the development of food products

Cited by 44 publications

References 179 publications

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Anthocyanins in Chronic Diseases: The Power of Purple

Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges

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