Jacaranone Derivatives with Antiproliferative Activity from Crepis pulchra and Relevance of This Group of Plant Metabolites

Abstract

Jacaranones are a small group of specific plant metabolites with promising biological activities. The occurrence of jacaranones is limited to only a few plant families, with Asteraceae being the most abundant source of these compounds. Therefore, jacaranones can also serve as chemotaxonomic markers. Our phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone, 2,3-dihydro-2-hydroxyjacaranone, 2,3-dihydro-2-methoxyjacaranone), and (6R,9S)-3-oxo-α-ionol-β-d-glucopyranoside, fulgidic acid, 12,15-octadecadienoic acid methyl ester, scopoletin and apigenin-7-O-β-d-glucoside. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae. Jacaranone derivatives were subjected to an in vitro antiproliferative assay against a panel of human cancer cell lines (MCF-7, MDA-MB-231, HeLa, and C33A), revealing high or moderate activities, with IC50 values ranging from 6.3 to 26.5 μM.

Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines

“…The cells were incubated with the tested substances for 72 h, and cisplatin (Ebewe Pharma GmbH, Unterach, Austria) was included as a reference agent. All details of these assays have been described earlier [23]. Cell growth was determined by measuring the optical density (OD) at 550 nm (ref.…”

New Insights into the Research of Bioactive Compounds from Plant Origins with Nutraceutical and Pharmaceutical Potential

“…Moreover, they can serve as chemotaxonomic markers. The phytochemical investigation of Crepis pulchra L. (Asteraceae) resulted in three jacaranone derivatives (jacaranone; 2,3-dihydro-2-hydroxyjacaranone; and 2,3-dihydro-2-methoxyjacaranone) [ 11 ]. This is the first report on the isolation of jacaranones from a species belonging to the Cichorioideae subfamily of Asteraceae.…”