Jaceosidin inhibits the progression and metastasis of NSCLC by regulating miR-34c-3p/Integrin α2β1 axis

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

“…There are various previous studies on these active ingredients. Studies have revealed that Jaceosidin is able to induce apoptosis in gastric cancer cells by regulating ROS-mediated signaling pathways and is able to inhibit the progression and metastasis of NSCLC . Luteolin performs various anticancer effects mainly by inhibiting proliferation and invasion, stimulating apoptosis, intercepting the cell cycle, regulating autophagy and immunity, inhibiting inflammatory responses, inducing iron death and pyroptosis, and epigenetic modifications .…”

“…Studies have revealed that Jaceosidin is able to induce apoptosis in gastric cancer cells by regulating ROS-mediated signaling pathways 50 and is able to inhibit the progression and metastasis of NSCLC. 51 Luteolin performs various anticancer effects mainly by inhibiting proliferation and invasion, stimulating apoptosis, intercepting the cell cycle, regulating autophagy and immunity, inhibiting inflammatory responses, inducing iron death and pyroptosis, and epigenetic modifications. 52 Lanatoside C can target the ZDHHC21/FASN axis for treating diffuse large B-cell lymphoma 53 and can inhibit the proliferation of cholangiocarcinoma and promote apoptosis.…”

Elucidation of Anti-Obesity Mechanisms of Phenolics in Artemisiae argyi Folium (Aiye) by Integrating LC-MS, Network Pharmacology, and Molecular Docking

“…Pharmacological research has shown that it has anti-virus, anti-bacteria, anti-oxidative, anti-inflammatory, anti-dermatitis, gastro-protective, and anti-cancer effects, mainly due to the presence of essential oils, flavonoids, and organic acids [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Pharmacological research has identified various anti-cancer components of Aiye, including jaceosidin, irigenin, luteolin, eriodictyol, apigenin, eupatilin, casticin, and artemetin [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. In obesity, the secretion of adipokines by adipose tissue was dysregulated, characterized by the up-regulation of proinflammation adipokines and the down-regulation of anti-inflammation adipokines [ 30 ].…”