Jährliche Konversionsrate von Patienten mit Gedächtnisbeeinträchtigung zur Alzheimerkrankheit: Der Einfluss von amnestischer MCI und die prädiktive Aussagekraft der neuropsychologischen Testung

Lehrner, Johann; Gufler, Renate; Guttmann, Giselher; Maly, Joachim; Gleiß, Andreas; Auff, Eduard; Dal‐Bianco, Peter

doi:10.1007/s00508-005-0428-6

Cited by 62 publications

(43 citation statements)

References 25 publications

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“…None of the SMI patients developed dementia. In the study by Lehrner et al (2005) the annual conversion rate to dementia for patients reporting memory problems but showing no memory deficit at testing was approximately 3%. In the Lehrner et al (2005) study there was no report of conversion rates from the state of no memory deficit at baseline to MCI.…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Lehrner et al (2005) the annual conversion rate to dementia for patients reporting memory problems but showing no memory deficit at testing was approximately 3%. In the Lehrner et al (2005) study there was no report of conversion rates from the state of no memory deficit at baseline to MCI. Our data are important because they indicate that the risk of developing dementia among fairly young patients seeking help for subjective memory complaints but with no objective memory decline is small.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge studies of the conversion rate of patients seeking help in a memory clinic because of memory problems, but showing no objective cognitive impairment are very rare (Lehrner et al, 2005;Glodzik-Sobanska et al, 2007;Vestberg et al, 2009). In our study we investigated the outcome of patients complaining of memory problems but with normal cognitive performance (SMI) as determined by neuropsychological examination.…”

Section: Discussionmentioning

confidence: 99%

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Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study

Elfgren¹,

Gustafson²,

Vestberg³

et al. 2010

Archives of Gerontology and Geriatrics

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The aims were to evaluate the cognitive performance and clinical diagnosis in patients (< 75 years) seeking help for subjective memory complaints, to determine the prevalence of certain psychiatric symptoms and to conduct follow-up examinations. At baseline 41% showed normal cognitive performance (subjective memory impairment; SMI), 37% fulfilled criteria for mild cognitive impairment (MCI) and 22% were classified as dementia. There were significant associations between the three groups and experiences of psychosocial stress and feelings of anxiety. The proportion of psychosocial stress was significantly higher in SMI vs. MCI and SMI vs.dementia. Feelings of anxiety was significantly higher in SMI vs. MCI. At the threeyear follow-up, 88% of the SMI patients remained stable SMI and 60% of the MCI patients remained stable. There was a significant reduction of psychosocial stress and moderate reduction of feelings of anxiety among the SMI patients. The findings indicate that the risk of patients with SMI developing dementia is small within a three year span. We propose that subjective memory complaints might be influenced by the presence of psychosocial stress and feelings of anxiety disturbing the memory processes and interfering with the patients' evaluation of their memory function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study

Elfgren¹,

Gustafson²,

Vestberg³

et al. 2010

Archives of Gerontology and Geriatrics

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“…In addition, the interval between neuropsychological testing and driving evaluation varied between patients with a mean of 170.61 days (SD = 261.68). Thus, it is possible, given the 6.5% annual conversion rate from self-reported memory decline to Alzheimer's disease in an outpatient memory clinic (Lehrner et al, 2005) that several patients from the present sample experienced further cognitive decline during the interval between neuropsychological testing and driving assessment. Future studies should explore the impact of comorbidity and the neuropsychological predictors of driving competence from a prospective approach.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Tests and Measurement of Comorbidity in Predicting Driving Competence among Memory Clinic Patients

Fausto¹,

McIntosh²,

Bonner³

et al. 2016

JPR

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Objective: Visuospatial, executive function, and attention abilities have previously been identified as predictors of driving competence, however specific neuropsychological tests that accurately predict driving outcomes have yet to be clearly defined. In addition, little is known about the impact of medical comorbidity on fitness to drive. The Future studies should examine the specificity of NPT predictive value using normal controls and the impact of medical comorbidity on driving competence in more heterogeneous samples.

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“…Amnestic mild cognitive impairment (aMCI), characterized by memory deficit, is a transitional stage between normal aging and AD [21]. Patients with aMCI have been reported to have an 8.6-fold higher conversion risk to AD compared with patients reporting memory problems without objective impairments on neu ropsychological testing [22]. …”

Section: Introductionmentioning

confidence: 99%

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer’s Disease Incidence in 4 Years of Follow-Up

Lauriola

Mangiacotti

Cascavilla

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer’s disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.

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Jährliche Konversionsrate von Patienten mit Gedächtnisbeeinträchtigung zur Alzheimerkrankheit: Der Einfluss von amnestischer MCI und die prädiktive Aussagekraft der neuropsychologischen Testung

Cited by 62 publications

References 25 publications

Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study

Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study

Neuropsychological Tests and Measurement of Comorbidity in Predicting Driving Competence among Memory Clinic Patients

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer’s Disease Incidence in 4 Years of Follow-Up

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