JAK/STAT signaling pathway gene expression is reduced following Nelf knockdown in GnRH neurons

Ko, Eun Kyung; Chorich, Lynn P.; Sullivan, Megan; Cameron, Richard S.; Layman, Lawrence C.

doi:10.1016/j.mce.2017.10.009

Cited by 15 publications

(2 citation statements)

References 55 publications

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“…Ko et al found that the expression of transcription factors and cell migration genes in GnRH neurons was frequently altered. The above results were found to be related to the regulation of the JAK-STAT signaling pathway by NELF in GnRH neurons [ 160 ]. Known as a hyper synchronized state of neurons, epilepsy is a functional brain disorder associated with the excessive synchronization of large populations of neurons.…”

Section: The Jak-stat Signaling Pathway In Epilepsymentioning

confidence: 99%

The JAK-STAT Signaling Pathway in Epilepsy

Sun

Cheng

et al. 2023

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Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence that inflammatory mediators and immune cells are involved in epileptic seizures. As more research is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of epilepsy will be revealed. The Janus kinase-signal transducer and transcriptional activator (JAK- STAT) signaling pathway is strongly associated with many immune and inflammatory diseases, At present, more and more studies have found that the JAK-STAT pathway is involved in the development and development of epilepsy, indicating the JAK-STAT pathway’s potential promise as a target in epilepsy treatment. In this review, we discuss the composition, activation, and regulation of the JAK-STAT pathway and the relationship between the JAK-STAT pathway and epilepsy. In addition, we summarize the common clinical inhibitors of JAK and STAT that we would expect to be used in epilepsy treatment in the future.

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