JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma

Liang, Feiguo; Liang, Hao; Li, Zuwei; Huang, Peiyuan

doi:10.1016/j.intimp.2020.106706

Cited by 27 publications

(36 citation statements)

References 49 publications

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“…Previous studies have also suggested that JAKs serve as biomarkers in certain types of cancers. In clear cell renal cell carcinoma, JAK3 acted as a novel biomarker and was associated with immune infiltration [ 26 ]. Another study revealed that JAK2 was a prognostic biomarker in skin cutaneous melanoma and was involved in gene regulation [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

Meng

Ding

et al. 2020

BioMed Research International

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Background. Stomach adenocarcinoma (STAD) is one of the most common malignant tumors. The Janus kinases (JAKs) play a significant part in cellular biological process, inflammation, and immunity. The roles of JAKs in STAD are still not systematically described. Methods. A series of bioinformatics tools were used to clarify the role of JAKs in STAD. Results. JAK3/TYK2 levels were significantly increased in STAD during subgroup analyses based on gender, tumor grade, cancer stages, and nodal metastasis status. STAD patients with high levels of JAK3/TYK2 had poor overall survival, postprogression survival, and first progression. Immune infiltration revealed a significant correlation between JAK3/TYK2 expression and the abundance of immune cells as well as immune biomarker expression in STAD. JAK3/TYK2 was associated with the adaptive immune response, chemokine signaling pathway, and JAK-STAT signaling pathway. Conclusions. JAK3 and TYK2 serve as prognostic biomarkers and are associated with immune infiltration in STAD.

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Section: Discussionmentioning

confidence: 99%

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

Meng

Ding

et al. 2020

BioMed Research International

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“…These are consistent with the findings that ACE2 in KIRC were primarily involved in the cell cycle, ribosomal activity, and immune infiltration. Previous studies suggest that JAK3 is used as a biomarker and is associated with immune infiltration in patients with KIRC [ 7 ]. Another study found that alterations in the JAK3 pathway were involved in CD8 T cell immune deviation in RCC [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that immune infiltration is significantly linked to the survival of KIRC patients. [ 6 , 7 ]. Immunotherapy has been suggested as the treatment for metastatic KIRC [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19

Niu

Zhu

Shao

et al. 2021

Journal of Oncology

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Background. KIRC is one of the most common cancers with a poor prognosis. ACE2 was involved in tumor angiogenesis and progression in many malignancies. The role of ACE2 in KIRC is still ambiguous. Methods. Various bioinformatics analysis tools were investigated to evaluate the prognostic value of ACE2 and its association with immune infiltration in KIRC. Results. ACE2 was shown to be downregulated in KIRC at the mRNA and protein level. Low expression of ACE2 protein in KIRC patients was observed in subgroup analyses based on gender, age, weight, tumor grade, and cancer stage. Upregulation of ACE2 in KIRC was associated with a favorable prognosis. ACE2 mRNA expression showed a positive correlation with the abundance of immune cells (B cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells) and the level of immune markers of different immune cells in KIRC. ACE2 expression could affect, in part, the immune infiltration and the advanced cancer stage. Moreover, enrichment analysis revealed that ACE2 in KIRC were mainly involved in translation factor activity, immunoglobulin binding, metabolic pathways, transcriptional misregulation in cancerous cells, cell cycle, and ribosomal activity. Several ACE2-associated kinases, miRNA, and transcription factor targets in KIRC were also identified. Conclusion. ACE2 was downregulated in KIRC and served as a prognostic biomarker. It was also shown to be associated with immune infiltration.

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“…Thus, we subsequently explored the possible functions and mechanisms of ARNTL2 through GSEA analysis, the results indicated that ARNTL2 might participated in the signaling pathways including T cell receptor signaling pathway, renal cell carcinoma, focal adhesion, JAK-STAT signaling pathway and cell cycle pathway. JAK-STAT signaling pathway has been implicated in carcinogenesis and immune in ltration of ccRCC [24,25], Fang et al reported simvastatin could inhibit the growth and metastasis of renal cancer cell growth through JAK2/STAT3, ERK and AKT/mTOR pathway [26]. Miao et al discovered that the alterations of JAK-STAT and immune signaling pathways in PBRM1-de cent renal cancer cells [5].…”

Section: Discussionmentioning

confidence: 99%

Upregulation of ARNTL2 Predicts Poor Survival for Clear Cell Renal Cell Carcinoma and Explores its Associations with PD-L1 and Immune Infiltration

Wang

Ying

et al. 2021

Preprint

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Background: Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2) pertain to the PAS superfamily. Emerging evidences have demonstrated the carcinogenic roles of transcription factor ARNTL2 in human malignancies, while its roles in ccRCC remain elusive. We sought to explore the comprehensive roles of ARNTL2 in ccRCC and place major emphasis on its correlations with tumor immunity.Methods: The available data from GEO, TCGA and GTEx database were combined with our ccRCC patient tissues to verify the upregulation of ARNTL2, Kaplan–Meier survival curve analysis, Cox regression analyses (including univariate and multivariate) were utilized to evaluate the prognostic values of ARNTL2, the potential biological mechanisms of ARNTL2 were analyzed by using GSEA method. The ssGSEA and xCell algorithm were employed to assess the correlations of ARNTL2 expression with tumor immune microenvironment (TIME), The spearman analyses were applied to investigate the relationships between ARNTL2 expression and the tumor mutational burden (TMB), PD-L1 expression and microsatellite instability (MSI) in pan-cancer.Results: ARNTL2 was overexpressed in ccRCC and increased ARNTL2 expression strongly linked to advanced clinical stage and unfavorable overall survival. ARNTL2 was recognized as an independent prognostic marker through cox regression analyses. A prognostic nomogram was subsequently constructed to predict 1-, 3- and 5-year overall survival via integrating ARNTL2 expression with other clinicopathologic variables. GSEA analysis revealed that the focal adhesion, T cell receptor, cell cycle and JAK-STAT signaling pathway were remarkably enriched in high ARNTL2 samples. xCell analysis suggested that high expression of ARNTL2 exhibited an immune infiltration status similar to CD8+ inflamed ccRCC subtype, which characterized by a high infiltration level of CD8+ T cell and elevated expression level of the immune escape biomarkers such as PD-L1, PD-L2, PD1 and CTLA4. Further pan-cancer analysis indicated that ARNTL2 was tightly linked to TMB, MSI, PD-L1 expression, tumor immunity and poor OS in diverse cancer types.Conclusions: ARNTL2 is an independent adverse predictor of ccRCC patient survival and tightly linked to TMB, MSI, PD-L1 expression and immunity.

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JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma

Cited by 27 publications

References 49 publications

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19

Upregulation of ARNTL2 Predicts Poor Survival for Clear Cell Renal Cell Carcinoma and Explores its Associations with PD-L1 and Immune Infiltration

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