JALA Special Issue: New Developments in Biosensing Technologies

Li, Yiyang

doi:10.1177/2211068215586754

Cited by 5 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Advances in the second generation of biosensors can be characterized by the application of antibodies or receptor proteins as molecular recognition elements, and signal converters are diverse, including field effect semiconductor devices, field effect semiconductors (FETs), optical fibers, piezoelectric crystal transistors, and surface acoustic wave devices (SAWs). The third generation of biosensors can be characterized by compactness, autonomy, and an instantaneous observation capability [ 30 , 31 ]. Microelectromechanical systems (MEMS) are used to fabricate array biosensors, but most of them are immunosensors.…”

Section: Introductionmentioning

confidence: 99%

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

et al. 2022

View full text Add to dashboard Cite

In this study, a biochip was fabricated using a light-absorbing layer of a silicon solar element combined with serrated, interdigitated electrodes and used to identify four different types of cancer cells: CE81T esophageal cancer, OE21 esophageal cancer, A549 lung adenocarcinoma, and TSGH-8301 bladder cancer cells. A string of pearls was formed from dielectrophoretic aggregated cancer cells because of the serrated interdigitated electrodes. Thus, cancer cells were identified in different parts, and electron–hole pairs were separated by photo-excited carriers through the light-absorbing layer of the solar element. The concentration catalysis mechanism of GSH and GSSG was used to conduct photocurrent response and identification, which provides the fast, label-free measurement of cancer cells. The total time taken for this analysis was 13 min. Changes in the impedance value and photocurrent response of each cancer cell were linearly related to the number of cells, and the slope of the admittance value was used to distinguish the location of the cancerous lesion, the slope of the photocurrent response, and the severity of the cancerous lesion. The results show that the number of cancerous cells was directly proportional to the admittance value and the photocurrent response for all four different types of cancer cells. Additionally, different types of cancer cells could easily be differentiated using the slope value of the photocurrent response and the admittance value.

show abstract

Section: Introductionmentioning

confidence: 99%

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

Biotechnology in Medicine: Advances-II

Rajan

Bhat²,

Maity

et al. 2022

Fundamentals and Advances in Medical Biotechnology

View full text Add to dashboard Cite

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

et al. 2022

View full text Add to dashboard Cite

Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but the factors that trigger systemic inflammation have not been fully elucidated. Lipopolysaccharide (LPS) is a component of the membrane of Gram-negative bacteria present in the gut that can translocate into the systemic circulation, causing non-septic, low-grade endotoxaemia. Gut dysbiosis is a major determinant of low-grade endotoxaemia via dysfunction of the intestinal barrier scaffold, which is a prerequisite for LPS translocation into the systemic circulation. Experimental studies have demonstrated that LPS is present in atherosclerotic arteries but not in normal arteries. In atherosclerotic plaques, LPS promotes a pro-inflammatory status that can lead to plaque instability and thrombus formation. Low-grade endotoxaemia affects several cell types, including leukocytes, platelets and endothelial cells, leading to inflammation and clot formation. Low-grade endotoxaemia has been described in patients at risk of or with overt cardiovascular disease, in whom low-grade endotoxaemia was associated with atherosclerotic burden and its clinical sequelae. In this Review, we describe the mechanisms favouring the development of low-grade endotoxaemia, focusing on gut dysbiosis and changes in gut permeability; the plausible biological mechanisms linking low-grade endotoxaemia and atherothrombosis; the clinical studies suggesting that low-grade endotoxaemia is a risk factor for cardiovascular events; and the potential therapeutic tools to improve gut permeability and eventually eliminate low-grade endotoxaemia.

show abstract

JALA Special Issue: New Developments in Biosensing Technologies

Cited by 5 publications

References 63 publications

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

Biotechnology in Medicine: Advances-II

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

Contact Info

Product

Resources

About