Jalur Sinyal TGF-β Berperan Dalam Self Renewal, Diferensiasi, Dan Proliferasi Stem Cell

Aisyah, Riandini; Jatmiko, Safari Wahyu

doi:10.22219/sm.vol15.smumm1.8002

Cited by 2 publications

(2 citation statements)

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“…Molecules that can convert TGF-β into active are metalloproteinases (MMP-2 and MMP-9). In conditions of tissue injury and inflammation, TGF-β triggers proliferation by activating other growth factors such as connective tissue growth factor (CTGF), platelet-derived growth factor (PDGF), or epidermal growth factor (EGF) [19], [20], [21], [22], [23].…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the Smad protein, TGF-β can also activate other signaling systems, such as Erk1/2, JNK, TAK1, PI3K, and p38 MAPK. This signaling system plays a role in various cell activities, such as cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, immune response, and epithelialmesenchymal cell transition [20], [21], [22], [23].…”

Section: Discussionmentioning

confidence: 99%

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Exposure Time of Silica Dust and the Incidence of Oxidative Stress, Inflammation, and Fibrosis in Rat Lungs

Artana

Artini²,

Arijana³

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Until now, exposure to silica dust is still a health problem worldwide. Silica exposure in the lungs will cause pulmonary fibrosis which is initiated by inflammation. However, the results of several studies regarding the duration of inflammation and fibrosis are still inconsistent. There was a role of oxidative stress in silicosis, but there were also inconsistencies in terms of when oxidative stress occurs in silica exposure. AIM: This study aimed to study the toxic effects of silica dust exposure by looking at the picture of inflammation and fibrosis and malondialdehyde (MDA) levels in lung tissue during the observation period of 7 days, 14 days, 21 days, and 28 days. METHODS: This study used a randomized post-test only control group design. The research sample was male Wistar rat (Rattus norvegicus), aged 6–10 weeks, body weight 150–200 g (divided into 5 groups: Control group, day 7 group, group day 14, group day 21, and group day 28). We administered silica suspension through intratracheal injection of 30 mg/rat on 0.5 mL of volume. Examination of MDA level was using the ELISA technique; histopathological examination of the liver used hematoxylin-eosin (HE) staining to determine inflammation and fibrosis. Statistical test using one-way ANOVA or Kruskal–Wallis followed by post hoc test. RESULTS: The results of our study found that intratracheal silica exposure increased MDA levels on the 7th day, increased the accumulation of collagen from the 14th day, and increased the pulmonary inflammation score on the 14th day (p < 0.05). CONCLUSIONS: It was concluded that silica exposure caused significant oxidative stress on day 7 as well as significant inflammation and pulmonary fibrosis on day 14.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure Time of Silica Dust and the Incidence of Oxidative Stress, Inflammation, and Fibrosis in Rat Lungs

Artana

Artini²,

Arijana³

et al. 2022

Open Access Maced J Med Sci

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The Role of Oligomeric-Grape Seed Proanthocyanidine Extract (O-GSPE) on Cholestasis Liver Damage in Animal Model

Widyawati,

Misaco Yuniarti,

Sektiari Lukiswanto

2024

RJPT

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The use of herbal plants as an alternative treatment for hepatobiliary disease is still being carried out.This study plans to examine the capability of oligomeric- grape seed proanthocyanidine extract (O-GSPE) in shielding the liver from injury brought about by cholestasis, which is prompted by bile duct ligation (BDL) as a creature model. Grown-up male rats were utilized and haphazardly separated into 3 treatment gatherings. C- was the negative control bunch, bile duct ligation (BDL) was the bunch that was treated with bile duct ligation (BDL) and the bile duct ligation (BDL)+oligomeric- grape seed proanthocyanidine extract (O-GSPE) bunch was given the bile duct ligation (BDL) treatment and given oligomeric- grape seed proanthocyanidine extract (O-GSPE) orally at measurements of 400mg/kg BW/day, beginning on the moment day after bile duct ligation (BDL) and given for 21 days. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT) were assessed employing a spectrophotometer; interleukin 6 (IL-6) and transforming growth factor beta 1(TGF-β1) were assessed utilizing histopathological examination with Hematoxylin and Eosin (HE) staining and immunohistochemistry. In this study, the results showed that liver morpho-function was significantly improved by the administration of oligomeric- grape seed proanthocyanidine extract (O-GSPE).

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Jalur Sinyal TGF-β Berperan Dalam Self Renewal, Diferensiasi, Dan Proliferasi Stem Cell

Cited by 2 publications

References 1 publication

Exposure Time of Silica Dust and the Incidence of Oxidative Stress, Inflammation, and Fibrosis in Rat Lungs

Exposure Time of Silica Dust and the Incidence of Oxidative Stress, Inflammation, and Fibrosis in Rat Lungs

The Role of Oligomeric-Grape Seed Proanthocyanidine Extract (O-GSPE) on Cholestasis Liver Damage in Animal Model

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