Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells

Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15

“…Baohuoside I (also known as icariside II) is the main active flavonoid component of H. epimedii (Qian et al, 2012;Zhai et al, 2013;Yu et al, 2013;Xiao et al, 2014). Baohuoside I can induce apoptosis in human non-small cell lung cancer cells (NSCLC) via reactive oxygen speciesmediated mitochondrial pathway and also inhibits the growths of U266 multiple myeloma and pre-osteoclastic RAW264.7 cells (Choi et al, 2008;Kim et al, 2011;Jin et al, 2012a;Song et al, 2012;Liu et al, 2014).…”

D-α-Tocopheryl polyethylene glycol succinate/Solutol HS 15 mixed micelles for the delivery of baohuoside I against non-small-cell lung cancer: optimization and in vitro, in vivo evaluation

“…[1][2][3] Baohuoside I can induce apoptosis in human non-small-cell lung cancer (NSCLC) cells via reactive oxygen species-mediated mitochondrial pathway and also inhibits the growth of U266 multiple myeloma and preosteoclastic RAW264.7 cells. [4][5][6][7] Baohuoside I has very poor solubility in water. Moreover, baohuoside I possesses a low absorptive permeability and a high rate of efflux via apical efflux transporters such as multidrug resistance-associated proteins 1 and 2 (MRP 1 and MRP 2) and P-glycoprotein (P-gp).…”

Induction of Apoptosis by Icariside II through Extrinsic and Intrinsic Signaling Pathways in Human Breast Cancer MCF7 Cells

“…15) Similar findings for IcaS have recently been recorded demonstrating that IcaS induced apoptosis by such means as attenuating the HIF-1 protein level in human osteosarcoma cells, 16) suppressing the COX-2/ PGE2 pathway in prostate cancer PC-3 cells, 17) and blocking the STAT3 signaling pathway in U266 multiple myeloma cells. 18) There have also been several reports of other prenylflavonoids derived from Epimedium as an anticancer agent to MCF7 cells, 19,20) Hec1A cells, 21) PC-3 cells, 22) HEPG2 cells, 23,24) SMMC-7721 cells, 25) and SK-Hep-1 cells. 26) However, the paucity of literature y To whom correspondence should be addressed.…”