Janus amphiphilic nanofiber membranes synergistically drive antibacterial and anti-inflammatory strategies for skin wound healing

Shi, Yupeng; Zhou, Mengyang; Zhao, Shuo; Li, Haotian; Wang, Wenhao; Cheng, Jingliang; Jin, Lin; Wang, Yifei

doi:10.1016/j.matdes.2023.111778

Cited by 25 publications

(9 citation statements)

References 43 publications

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“…The Janus amphiphilic nanofibers composed by a hydrophobic side of PLGAV-CuS NPs and a hydrophilic side of poly(vinyl alcohol) mupirocin nanofiber (PVAM) exhibited a biphasic drug release mechanism. The cumulative release of the hydrophilic antimicrobial drug, mupirocin, from PLGAV-CuS/PVAM nanofibers enabled a continuous and slow release, reaching 89.36% after 24 h of incubation [24]. The sustained release of mupirocin can be attributed to the hydrogen bonding between the drug and the PLGAV-CuS/PVAM.…”

Section: Side-by-side Electrospinningmentioning

confidence: 92%

“…Shi et al used side-by-side electrospinning to combine a solution of 10% (w/v) PLGA with an anti-inflammatory drug (0.2% (w/v) valsartan, V) and a solution of 15% (w/v) PVA with copper sulfide nanoparticles (CuS NPs) and an antibacterial drug (mupirocin, M) [24]. Both solutions were placed in two different syringes with 26 G blunted spinning needles and electrospun at a constant feeding rate of 1.0 mL/h, using a working distance of 20 cm and an applied voltage of 15 kV.…”

Section: Side-by-side Electrospinningmentioning

confidence: 99%

“…This result confirms that the diffusion of hydrophobic drugs in a hydrophilic environment is hindered. Therefore, the PLGAV-CuS/PVAM Janus nanofibers initially released mupirocin more quickly, and then, the valsartan and remaining mupirocin were continuously released, achieving tunable antibacterial and anti-inflammatory gradient drug release systems [24].…”

Section: Side-by-side Electrospinningmentioning

confidence: 99%

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Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

C. Gouveia,

Mouro

2024

Electrospinning - Theory, Applications, and Update Challenges

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Electrospinning, a remarkable and versatile technique has been related to medical textiles, aiming to produce nanomaterials for drug delivery and tissue regeneration applications. Furthermore, electrospun nanofibrous materials with unique properties as favorable pore size distribution, porosity, surface area, and wettability, along with effective mechanical properties, are the frontrunner solutions. Also, the features of the nanofibrous structures can be designed and optimized by controlling electrospinning parameters related to the solution properties, the setup parameters, and the environmental conditions to design nanofibrous textile materials for the desired applications. Further, to accomplish the required functionality of the drug-delivery systems, a rather broad range of drugs have been loaded into the nanofibers using different electrospinning techniques, namely the blending, side-by-side, coaxial, tri-axial, emulsion, and multi-needle electrospinning, in order to accomplish specific drug-release profiles of the designed nanofibrous textiles. Thus, this chapter describes the different electrospinning techniques that have been utilized in the production of the textile nanofibrous materials as the application of these materials in bone, nerve, periodontal, and vascular regeneration, as well as in wound dressings, personal-protective-equipment (PPE), and cancer treatment, providing an overview of the recent studies and highlighting the current challenges and future perspectives for their medical applications.

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Section: Side-by-side Electrospinningmentioning

confidence: 92%

Section: Side-by-side Electrospinningmentioning

confidence: 99%

Section: Side-by-side Electrospinningmentioning

confidence: 99%

See 1 more Smart Citation

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

C. Gouveia,

Mouro

2024

Electrospinning - Theory, Applications, and Update Challenges

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“…In a similar study, Shi et al prepared amphiphilic Janus nanofiber membranes loaded with copper sulfide nanoparticles, mupirocin and valsartan using polyvinyl alcohol, polylactic acid-glycolic acid. 102 Their prepared Janus nanofiber membranes possessed obvious amphiphilic characteristics and were capable of sustained release of the antimicrobial agent mupirocin in a hydrophilic environment. In addition, the photothermal effect of the amphiphilic Janus nanofiber membrane can also control the release of the anti-inflammatory agent valsartan.…”

Section: Electrospun Nanofibermentioning

confidence: 99%

Recent progress of electrospun nanofibers as burning dressings

Zhang,

Yang,

Gong

et al. 2024

RSC Adv.

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“…Wound dressings are made using a variety of techniques, according to their intended structure and material. Furthermore, various wound dressing structures have been explored in hopes of improving wound healing, including sponges [38], films [39], hydrocolloids [40], nanofiber membranes [41], and hydrogels [42].…”

Section: Introductionmentioning

confidence: 99%

Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications

Hassan,

Diab,

Abd El-Wahab

et al. 2023

Molecules

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The purpose of this study was to enhance the antimicrobial activity of bagasse paper by coating the paper with bismuth oxide (Bi2O3) and using it to accelerate the process of wound healing. Paper sheets were prepared from sugarcane waste (bagasse). First, the paper sheets were coated with different Bi2O3 concentrations to improve the antimicrobial activity of the paper. After that, the paper sheets were allowed to dry in an oven at 50 °C for 3 h. Then, in vitro antimicrobial activity was evaluated against different microbial species, including Gram-negative bacteria (i.e., Klebsiella pneumonia, Escherichia coli) and Gram-positive bacteria (i.e., Staphylococcus aureus, Streptococcus pyogenes). The obtained results showed that the paper coated with 25% and 100% Bi2O3 had activity against all models of bacteria; however, the paper coated with 100% Bi2O3 composite had the strongest inhibitory effect. Then, bagasse paper was coated with 100% Bi2O3 and different antibiotics, to investigate their wound-healing potency in a wounded rat model for 14 days. Moreover, the paper coated with 100% Bi2O3 inhibited the cellular migration in vitro. Conclusively, coating paper with Bi2O3 enhances the wound-healing potential when applied to wounds. This impact could be ascribed to Bi2O3’s broad antibacterial activity, which reduced infection and accelerated the healing process.

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Janus amphiphilic nanofiber membranes synergistically drive antibacterial and anti-inflammatory strategies for skin wound healing

Cited by 25 publications

References 43 publications

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

Development of Drug-Delivery Textiles Using Different Electrospinning Techniques: A Review

Recent progress of electrospun nanofibers as burning dressings

Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications

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