Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization—Brief Report

Wang, Yung-Chun; Cai, Dunpeng; Cui, Xiaobing; Chuang, Ya-Hui; Fay, William P.; Chen, Shiyou

doi:10.1161/atvbaha.121.316293

Cited by 2 publications

(1 citation statement)

References 47 publications

(57 reference statements)

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“…Jak3 contributes to mucosal development of gastrointestinal tissue by performing mechanistic roles in mucosal wound repair, homeostasis, epithelial barrier functions, and epithelial-mesenchymal transition 32 . In the regeneration of endothelium after vascular injury also, Jak3 can regulate the reendothelization following mechanical injury, which can modulate neointimal formation 33 . Jak3 can modulate myocardial injury by reducing inflammation-induced apoptotic damage 34 , and spinal cord injury can be regulated by participating transcriptional factors for microglial cell differentiation 35 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Janus Kinase 3 Inhibitor on Sebaceous Gland Regeneration during Skin Wound Healing

Jo,

Kim,

Woo

et al. 2023

Ann Dermatol

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Background Janus kinase (Jak) 3 has recently been shown as a beneficial target for the treatment of chronic inflammatory diseases, such as psoriasis and alopecia areata. The role of Jak3 in tissue repair and remodeling is emerging. Objective This study aimed to investigate the role of Jak3 signaling in the remodeling of the sebaceous gland (SG) during skin wound repair, and the development of in vitro SGs. Methods Mouse skin tissue (ICR mouse) was obtained from the recovered skin eight days after a 4 mm biopsy punch wound. To observe the role of Jak3, the selective inhibitors WHI-p131 and PF06651600 was administered. Formation of in vitro SG was examined using primary sebocyte cultures obtained postnatally from 3-day-old mice. Results The data showed that SGs showed highly positive signals with anti-isolectin B4, which also used for detection of angiogenetic vessels and the basal epidermis. Isolectin B4 could be a good indicator of SGs. The Jak3 inhibitors significantly reduced the area and volume of SG remodeling with reduced expression of p-Jak3. In addition, the area of cultured intact SG in vitro was significantly decreased in a concentration-dependent manner by Jak3 inhibition. Conclusion These data showed that Jak3 signaling is a potent regulator to develop SGs. Jak3 inhibition did not decrease the number of sebocytes in SGs but decreased the area and volume of SG remodeling. Therefore, Jak3 inhibition may be a potential target for the treatment of SG hyperplasia and associated skin diseases.

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Section: Discussionmentioning

confidence: 99%

Effect of Janus Kinase 3 Inhibitor on Sebaceous Gland Regeneration during Skin Wound Healing

Jo,

Kim,

Woo

et al. 2023

Ann Dermatol

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Genome-Wide DNA Methylation Profiling Reveals Low Methylation Variability in Moyamoya Disease

Tokairin,

Ito,

Lee

et al. 2024

Transl. Stroke Res.

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Moyamoya disease (MMD) is a chronic cerebrovascular disorder that can lead to stroke and neurological dysfunctions. Given the largely sporadic nature and the role of gene-environment interactions in various diseases, we examined epigenetic modifications in MMD. We performed genome-wide DNA methylation using Illumina 850 K Methylation EPIC BeadChip, in two racially distinct adult female cohorts: a non-Asian cohort (13 MMD patients and 7 healthy controls) and an Asian cohort (14 MMD patients and 3 healthy controls). An additional external cohort with both sexes (females: 5 MMD patients and 5 healthy controls, males: 5 MMD patients and 5 healthy controls) was included for validation. Our findings revealed strikingly low DNA methylation variability between MMD patients and healthy controls, in both MMD female cohorts. In the non-Asian cohort, only 6 probes showed increased variability versus 647 probes that showed decreased variability. Similarly, in the Asian cohort, the MMD group also displayed a reduced methylation variability across all 2845 probes. Subsequent analysis showed that these differentially variable probes are located on genes involved in key biological processes such as methylation and transcription, DNA repair, cytoskeletal remodeling, natural killer cell signaling, cellular growth, and migration. These findings mark the first observation of low methylation variability in any disease, contrasting with the high variability observed in other disorders. This reduced methylation variability in MMD may hinder patients’ adaptability to environmental shifts, such as hemodynamic stress, thereby influencing vascular homeostasis and contributing to MMD pathology. These findings offer new insights into the mechanisms of MMD and potential treatment strategies.

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Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization—Brief Report

Cited by 2 publications

References 47 publications

Effect of Janus Kinase 3 Inhibitor on Sebaceous Gland Regeneration during Skin Wound Healing

Effect of Janus Kinase 3 Inhibitor on Sebaceous Gland Regeneration during Skin Wound Healing

Genome-Wide DNA Methylation Profiling Reveals Low Methylation Variability in Moyamoya Disease

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