Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

Zhang, Yifan; Wan, Yilin; Liao, Yunyan; Hu, Yanjie; Jiang, Tao; He, Ting; Bi, Weihong; Lin, Jing; Gong, Peng; Tang, Longhua; Huang, Peng

doi:10.1016/j.scib.2019.12.024

Cited by 102 publications

(57 citation statements)

References 45 publications

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“…Recently, the synergistic cancer therapy is an emerging trend of cancer therapy, because it can maximize the therapeutic efficacy of each component. [ 25c,38 ] The enhanced cellular uptake and tumor targeting by low‐dose PDT might be attributed to the enhanced cell membrane permeability of tumor cells after PDT, and this increase was positively correlated with the ROS generated by PDT (Figure 3c). Thus, the increase of tumor cell membrane permeability might be owing to the damage of ROS on lipids, polysaccharide, and other macromolecules on the cell membrane.…”

Section: Figurementioning

confidence: 99%

Six Birds with One Stone: Versatile Nanoporphyrin for Single‐Laser‐Triggered Synergistic Phototheranostics and Robust Immune Activation

et al. 2020

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Simultaneous photodynamic therapy (PDT) and photothermal therapy (PTT) can reduce the risks of drug leakage, body burden, and preparation complexity in traditional combination PDT/PTT. Here, a versatile nanoporphyrin (Pp18‐lipos) self‐assembled from lipid–purpurin 18 conjugates (Pp18‐lipids) and pure lipids is presented. The as‐prepared Pp18‐lipos with 2 mol% Pp18‐lipids can perform effective PDT and fluorescence imaging. The Pp18‐lipos with 65 mol% Pp18 can perform potent PTT and photoacoustic imaging. The chelation of Mn2+ endows the Pp18‐lipids‐Mn2+ a high T1‐weighted magnetic resonance imaging contrast. Notably, pretreatment of low‐dose PDT facilitates the endocytosis and tumor accumulation of Pp18‐lipos, thus achieving synergistic PDT/PTT. Upon exposure to a single 705 nm‐laser, the combination of PDT/PTT achieves a significantly higher tumor growth inhibition rate than PDT or PTT alone. In addition, it is found that the synergistic PDT/PTT triggers more potent anti‐tumor immune response including tumor infiltration of immune cells and release of related cytokines.

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Section: Figurementioning

confidence: 99%

Six Birds with One Stone: Versatile Nanoporphyrin for Single‐Laser‐Triggered Synergistic Phototheranostics and Robust Immune Activation

et al. 2020

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“…In recent years, glucose oxidase (GOx), as a natural oxidoreductase, is recognized as an excellent H 2 O 2 producer due to its high catalytic efficiency against β‐D‐glucose and adequate glucose supply in vivo. [ 8 ] Considerable efforts have been made to codeliver GOx and Fe‐based Fenton agents such as Fe 5 C 2 , [ 5b ] Fe 3 O 4 , [ 9 ] γ‐Fe 2 O 3 , [ 10 ] and ferrocene [ 11 ] to treat cancer. The consumption of intratumoral glucose by GOx catalysis led to an in situ elevation of H 2 O 2 level, subsequently the generated H 2 O 2 was converted into • OH by Fe 2+ ‐catalysis, resulting in enhanced tumor cells apoptosis and death.…”

Section: Methodsmentioning

confidence: 99%

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

et al. 2021

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Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (•OH). To overcome the current limitations of the insufficient endogenous H2O2 and the high concentration of glutathione (GSH) in tumor cells, an intelligent nanocatalytic theranostics (denoted as PGC‐DOX) that possesses both H2O2 self‐supply and GSH‐elimination properties for efficient cancer therapy is presented. This nanoplatform is constructed by a facile one‐step biomineralization method using poly(ethylene glycol)‐modified glucose oxidase (GOx) as a template to form biodegradable copper‐doped calcium phosphate nanoparticles, followed by the loading of doxorubicin (DOX). As an enzyme catalyst, GOx can effectively catalyze intracellular glucose to generate H2O2, which not only starves the tumor cells, but also supplies H2O2 for subsequent Fenton‐like reaction. Meanwhile, the redox reaction between the released Cu2+ ions and intracellular GSH will induce GSH depletion and reduce Cu2+ to Fenton agent Cu+ ions, and then trigger the H2O2 to generate •OH by a Cu+‐mediated Fenton‐like reaction, resulting in enhanced CDT efficacy. The integration of GOx‐mediated starvation therapy, H2O2 self‐supply and GSH‐elimination enhanced CDT, and DOX‐induced chemotherapy, endow the PGC‐DOX with effective tumor growth inhibition with minimal side effects in vivo.

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“…For example, Huang's group obtained the Janus‐type γFe 2 O 3 /SiO 2 NPs (JFSNs) and conjugated GOx on their surface. [ 52 ] The treatment process was described as follows. Firstly, the SiO 2 loaded GOx could catalyze the decomposition of Glu to facilitate the release of Fe ions in the TME.…”

Section: Different Kinds Of Nanomaterials‐based Nanoplatforms For Cdtmentioning

confidence: 99%

“…f) Schematic of JFSNs-GOx mediated dual-modal imaging and enhanced synergistic cancer starvation/CDT. Reproduced under the terms of the Creative Commons CC-BY license [52]. The Authors, Copyright 2020, Elsevier.…”

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confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

286

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Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

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Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

Cited by 102 publications

References 45 publications

Six Birds with One Stone: Versatile Nanoporphyrin for Single‐Laser‐Triggered Synergistic Phototheranostics and Robust Immune Activation

Six Birds with One Stone: Versatile Nanoporphyrin for Single‐Laser‐Triggered Synergistic Phototheranostics and Robust Immune Activation

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

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