Jatropham 5-O-β-D-Glucopyranoside from Lilium candidum L.

Mučaji, Pavel; Haladová, M; Eisenreichová, E; Budêšínský, Miloś; Ubik, Karel

doi:10.1135/cccc19961662

Cited by 2 publications

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“…) were prepared in the Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. Both compounds were isolated from fresh L. candidum bulbs (Mucaji et al, ; Eisenreichová et al, ). Extraction in 96% ethanol was performed several times, followed by vacuum processing.…”

Section: Methodsmentioning

confidence: 99%

Liliumcompounds kaempferol and jatropham can modulate cytotoxic and genotoxic effects of radiomimetic zeocin in plants and human lymphocytesIn vitro

2014

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Organisms are constantly exposed to the detrimental effect of environmental DNA-damaging agents. The harmful effects of environmental genotoxins could be decreased in a viable way by antimutagenesis. One of the modern approaches to reduce the mutagenic burden is based on exogenous natural and synthetic compounds that possess protective and antimutagenic potential against genotoxins. The natural compounds kaempferol and jatropham isolated from Lilium candidum were tested with respect to their potential to protect cells against the radiomimetic zeocin, as well as to their cytotoxic and genotoxic activities in two types of experimental eukaryotic test systems: Hordeum vulgare and human lymphocytes in vitro. Mitotic index (MI) was used as an endpoint for cytotoxicity; the frequency of chromosome aberrations (MwA) and the number of induced micronuclei (MN), as endpoints for genotoxicity/clastogenicity. Formation of aberration "hot spots" was also used as an indicator for genotoxicity in H. vulgare. Both kaempferol and jatropham were shown to possess a potential to modulate and decrease the cytotoxic and genotoxic/clastogenic effect of zeocin depending on the experimental design and the test system. Our data could be useful for health research programs, particularly in clarifying the pharmacological potential and activity of natural plant compounds. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 751-764, 2016.

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Section: Methodsmentioning

confidence: 99%

Liliumcompounds kaempferol and jatropham can modulate cytotoxic and genotoxic effects of radiomimetic zeocin in plants and human lymphocytesIn vitro

2014

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“…Many biologically active substances were isolated from an ethanolic extract of flowers and onions of L. candidum. These are mainly flavonoids (quercetin, isorhamnetin, kaempferol) Tappi et al [8], but numerous other bioactive substances have been found in the plant: carotenoids Tappi et al [9] steroidal alkaloids, pyrrole alkaloids (lilalin, jatrophan), steroids (beta-sitosterol) and steroid saponins of furostane and spinostane type, tannins, polysaccharides, organic acids and amino acids Haladova et al [10][11][12][13][14][15][16][17][18][19]. The structural formulas of some important Lilium compounds are shown in Figure 2.…”

Section: Modern Medicinementioning

confidence: 99%