Jaundice and Extreme Hypercholesterolemia After a Stroke

Fred, Herbert L.; Hariharan, Ramesh; Doucet, J; Mehta, Niraj

doi:10.1080/21548331.1996.11443343

Cited by 1 publication

(2 citation statements)

References 7 publications

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“…case reports of ticlopidine-induced cholestatic jaundice. [6][7][8][9][10][11][12][13][14][15][16][17] Most patients had documented liver test abnormalities 1-3 months after starting therapy, including elevations in aspartate aminotransferase, alanine aminotransferase, ␥glutamyl aminotransferase, alkaline phosphatase, and total and direct bilirubin. Symptoms of liver injury also were reported, including jaundice, dark urine, nausea, decreased appetite, and lightcolored stools.…”

Section: Discussionmentioning

confidence: 99%

“…All patients reported in the literature had documented liver function test abnormalities and symptoms of liver injury and were receiving ticlopidine at the time of the reaction. [6][7][8][9][10][11][12][13][14][15][16][17] Our patient is unusual in that he discontinued ticlopidine, had documented normal liver tests about 2 weeks later, and developed jaundice and liver test abnormalities approximately 4 weeks later. He had no changes in other drugs during that time.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Delayed‐Onset Ticlopidine‐Induced Cholestatic Jaundice

Kubin¹,

Sherman²,

Hussain

et al. 1999

Pharmacotherapy

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An 86-year-old man experienced a rash approximately 2 weeks after starting ticlopidine therapy, necessitating discontinuation of the drug. About 1 month later, despite discontinuation, he developed jaundice and liver test abnormalities. These resolved gradually over the next few months. Based on case reports and the drug's pharmacokinetic profile, a high index of suspicion for ticlopidine-induced jaundice is prudent in patients with recent exposure to the agent who have evidence of liver damage.

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