JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence

Prezioso, Carla; Pietropaolo, Valeria; Moens, Ugo; Ciotti, Marco

doi:10.1080/14737159.2023.2179394

Cited by 3 publications

(1 citation statement)

References 191 publications

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“…JCV can be categorized into two forms based on the structure of its noncoding regulatory region which are the archetype and rearranged variants [13]. The archetypal form of JCV includes a single copy of the promoter and enhancer [14] while rearranged variants including alterations in their genetic sequences that can affect various aspects of viral biology, including infectivity, replication, and pathogenicity and these variants may arise due to genetic mutations, recombination events, or other mechanisms [15]. In terms of nucleotide homology, JCV and BKV exhibit around 72% similarity with each other, and they both share 70% nucleotide homology with SV40 [16].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of JC and BK viruses among prostate cancer patients in Al-Najaf Al-Ashraf province

Kadhum,

Mezher

2024

BIO Web Conf.

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A total of 74 clinical samples Formalin-Fixed Paraffin-Embedded (FFPE) were collected from patients diagnosed with prostate cancer (PCa) aged between 41 and 90 years and these samples were obtained from patients treated at notable medical institutions like Al-Sadr Medical City and leading clinical laboratories in Al-Najaf City, Iraq, during the period of January to December 2023. Prostate cancer is considered a common malignant tumor in males, and studies are still investigating the possible relationship of the appearance of this disease with other factors, including viral infections, which were investigated in the current study in search of possible links between the presence of human BK oncolytic viruses (BKV). The JC (JCV) and the emergence of this disease. The current study indicated the potential role of the JCV virus in provoking prostatitis, which may lead to the emergence and development of prostate cancer in males compared to males who do not suffer from viral infection. The present study showed the absence of BKV virus DNA in prostate cancer tissue samples compared to the presence of JCV virus DNA, as the percentage of positive samples reached (11, 14.864%) compared to negative samples (63, 85.135%).

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