Jejucarbazoles A–C, carbazole glycosides with indoleamine 2,3-dioxygenase 1 inhibitory activity from<i>Streptomyces</i>sp. KCB15JA151

Kim, Gil Soo; Jang, Jun‐Pil; Kwon, Mincheol; Oh, Tae Hoon; Heo, Kyung Taek; Lee, Byeongsan; Lee, Jung-Sook; Ko, Sung-Kyun; Hong, Young‐Soo; Ahn, Jong Seog; Jang, Jae‐Hyung

doi:10.1039/d1ra02895b

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…More than half of all naturally derived antibiotics were isolated from actinomycetes, and 70% of these were found in Streptomyces [ 3 ]. We recently reported novel metabolites isolated from Streptomyces species, such as jejucarbazoles A, B, and C [ 4 ], aturanosides A and B [ 5 ], pentaminomycins A and B [ 6 ], and octaminomycins A and B [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

Jang

Nogawa

et al. 2022

J. Microbiol. Biotechnol.

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Materials and Methods General Experimental ProceduresThe specific rotations were measured on a JASCO P-1020 polarimeter (JASCO Corporation, Japan) that uses a 100-mm glass microcell. UV spectra were recorded on an Optizen 2120 UV spectrophotometer (Mecasys, Korea). The IR spectra were recorded on a Bruker VERTEX80V FT-IR spectrometer (Bruker, Germany). The NMR spectra were recorded on Bruker AVANCE HD 800 NMR spectrometer (Bruker, USA) at the Korea Basic Science Institute (KBSI) in Ochang, South Korea. Chemical shifts were referenced to a residual solvent signal (DMSO-d 6 δ H 2.50, δ C 39.51). High-resolution electrospray ionization mass spectrometry (HRESIMS) data were acquired A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and Highresolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.

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Section: Introductionmentioning

confidence: 99%

RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

Jang

Nogawa

et al. 2022

J. Microbiol. Biotechnol.

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Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Jang

Ahn

et al. 2022

Bioorganic & Medicinal Chemistry Letters

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Recent Progress in the Isolation and Bioactivities of Carbazole Alkaloids

Dau-Xuan,

Nguyen-Thi,

Vo-Cong

2024

Natural Product Communications

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Objective/Background Carbazole derivatives have a tricyclic skeleton, consisting of a central pyrrole ring fused with two benzene rings. Carbazole derivatives are an important class of nitrogen-containing heterocyclic compounds that are widely found in nature and in synthetic source. These heterocycles possess a wide range of bioactivities and some of them have been marketed as drugs for the treatment of various diseases. Although some review articles on carbazole alkaloids have appreared in the literature, they are quite outdated. The current study offers a comprehensive review on the isolation and bioactivities of carbazole alkaloids within a decade. The article might be useful for chemists who work in alkaloid chemistry as well as pharmaceutical area. Methods ‘Carbazole alkaloids’ was the most useful keyword to search for literature data. References have been collected from various resources such as Google Scholar, SciFinder, and PubMed. More than 70 electronic publications were obtained from these resources. Results More than 230 carbazole alkaloids have been isolated and structurally elucidated from different sources. Carbazole alkaloids possess a wide range of bioactivities, such as antimicrobial, antiimflamatory, anticancer, neuroprotective properties activities. Conclusion In this review article, we have summarized 66 studies on isolation and bioactivities of carbazole alkaloids in the literature. More than 230 carbazole alkaloid compounds have been isolated and identified. In addition, the article also gives an overview on bioactivities of carbazole alkaloids.

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Jejucarbazoles A–C, carbazole glycosides with indoleamine 2,3-dioxygenase 1 inhibitory activity fromStreptomycessp. KCB15JA151

Abstract: This study presents the isolation and structure elucidation of jejucarbazoles A–C, isolated from Streptomyces sp. KCB15JA15 and their inhibitory effect and molecular docking analysis against the IDO1 enzyme.

Cited by 3 publications

References 46 publications

RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity

Streptooctatins A and B, fusicoccane-type diterpenoids with autophagic activity from Streptomyces sp. KCB17JA11

Recent Progress in the Isolation and Bioactivities of Carbazole Alkaloids

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