Jejunal Adenocarcinoma—A Case Report with Review

Abstract

Primary Small bowel tumours are rare accounting for only 3-6% of GI neoplasm; 1-2% of these are malignant. Their presentation is usually with nonspecific symptoms that causes delay in diagnosis and consequently a worse outcome for the patient. We report a case of Jejunal adenocarcinoma where early diagnosis and treatment lead to good outcome.

Adenocarcinoma de yeyuno proximal: a propósito de un caso

“…En los datos de los exámenes de laboratorio se puede evidenciar anemia leve debido a la pérdida de sangre crónica y de etiología no identificada; ante esto, siempre se debe sospechar de un proceso neoplásico. Las pruebas de función hepática pueden revelar hiperbilirrubinemia en caso de tumores duodenales y una elevación de las transaminasas cuando existen metástasis hepáticas (13) .…”

“…La tomografía computarizada abdominal con contraste oral e intravenoso revela el sitio exacto y la extensión de la enfermedad local, con realce periférico intenso por el contraste intravenoso, así como la presencia de metástasis hepáticas. No obstante, es deficiente en la detección de tumores pequeños primarios, con una especificidad y sensibilidad del 57 %; es útil para la estadificación, pero para las patologías del intestino delgado deben usarse otras modalidades de imagen (13,14) .…”

Jejunal Adenocarcinoma: A Rare Case Report

“…As the small bowel carcinoma is rare, not much of information is available regarding the molecular aspects of these tumours, which could be of help in the planning, prevention, diagnosis and management of these tumours. (2) Males have a higher inclination for these malignancies. Increasing age is associated with higher incidence of small intestinal cancers.…”

“…They apparently have an neoplastic resistance by the large amount of alkaline fluid secretion and highly concentrated enzymes like benzopyrene, hydroxylase and high immunoglobulin level A, which dilutes and detoxifies the potential carcinogens and also preventing the prolonged exposure of carcinogens to the mucosa. (2) Small bowel also has a very limited number of bacteria as compared to the colon that are capable of transforming potential procarcinogens into their active breakdown products.…”

“…The delay of diagnosis is responsible for the presentation of these patients at advanced tumour stages. (1,2) Prognostic Factors: Age, Tumour size, Histological grade, Depth of invasion, Nodal involvement.…”