Jejunal immunoglobulin secretion in alcoholic patients with and without cirrhosis

Colombel, J F; Vaerman, Jean‐Pierre; Mesnard, B; Dehennin, Jean-Pierre; Rambaud, J C

doi:10.1016/0168-8278(91)90930-a

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…It was reported that patients with decompensated cirrhosis had reduced intestinal secretion of IgA compared with those with compensated cirrhosis. 83 By contrast, two other investigations showed no differences in the levels of IgA secretion 84 and IgA-secreting plasma cells. 85 To date, no studies have evaluated the changes in GALT related to chronic alcohol consumption and how ethanol and/or its metabolites could impact intestinal lymphoid structures and functions.…”

Section: Open Accessmentioning

confidence: 83%

Alcohol-associated bowel disease: new insights into pathogenesis

Maccioni,

Fu,

Horsmans

et al. 2023

egastro

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Excessive alcohol drinking can cause pathological changes including carcinogenesis in the digestive tract from mouth to large intestine, but the underlying mechanisms are not fully understood. In this review, we discuss the effects of alcohol on small and large intestinal functions, such as leaky gut, dysbiosis and alterations of intestinal epithelium and gut immune dysfunctions, commonly referred to as alcohol-associated bowel disease (ABD). To date, detailed mechanistic insights into ABD are lacking. Accumulating evidence suggests a pathogenic role of ethanol metabolism in dysfunctions of the intestinal tract. Ethanol metabolism generates acetaldehyde and acetate, which could potentially promote functional disruptions of microbial and host components of the intestinal barrier along the gastrointestinal tract. The potential involvement of acetaldehyde and acetate in the pathogenesis of the underlying ABD, including cancer, is discussed. We also highlight some gaps in knowledge existing in the field of ABD. Finally, we discuss future directions in exploring the role of acetaldehyde and acetate generated during chronic alcohol intake in various pathologies affecting different sites of the intestinal tract.

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Section: Open Accessmentioning

confidence: 83%

Alcohol-associated bowel disease: new insights into pathogenesis

Maccioni,

Fu,

Horsmans

et al. 2023

egastro

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“…In one study, patients with decompensated cirrhosis had reduced intestinal secretion of IgA compared to compensated alcohol-associated cirrhosis [71]. By contrast, two other studies reported similar levels of IgA secretion [72] and IgA-secreting plasma cells [73]. Characterization of IgA levels with different methods as well as characterization of IgA-plasma cells at different stages of ALD and possible impact of a period of abstinence before admission may partially explain these conflicting observations.…”

Section: Plasma Cellsmentioning

confidence: 97%

Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease

Maccioni

Leclercq

Schnabl

et al. 2021

IJMS

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Chronic alcohol consumption and alcohol-associated liver disease (ALD) represent a major public health problem worldwide. Only a minority of patients with an alcohol-use disorder (AUD) develop severe forms of liver disease (e.g., steatohepatitis and fibrosis) and finally progress to the more advanced stages of ALD, such as severe alcohol-associated hepatitis and decompensated cirrhosis. Emerging evidence suggests that gut barrier dysfunction is multifactorial, implicating microbiota changes, alterations in the intestinal epithelium, and immune dysfunction. This failing gut barrier ultimately allows microbial antigens, microbes, and metabolites to translocate to the liver and into systemic circulation. Subsequent activation of immune and inflammatory responses contributes to liver disease progression. Here we review the literature about the disturbance of the different host defense mechanisms linked to gut barrier dysfunction, increased microbial translocation, and impairment of liver and systemic inflammatory responses in the different stages of ALD.

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“…4). A decreased number of ileal goblet cells 108 , reduced mucus thickness in the ileum and colon 108,109 , a possible decrease in intestinal SIgA 110,111 , downregulation of small intestinal and colonic tight junction proteins 108,109 , and compromised Paneth cell function with decreased expression of AMPs 112,113 all contribute to impaired gut barrier function as observed in patients with cirrhosis and in experimental models. As a result, translocation of microbial products and live bacteria to mLNs add to mucosal, hepatic and systemic inflammation in liver disease (reviewed previously 114 ) 113,115,116 .…”

Section: Review Articlementioning

confidence: 99%

Gut–liver axis: barriers and functional circuits

Pabst

Hornef

Schaap

et al. 2023

Nat Rev Gastroenterol Hepatol

102

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Jejunal immunoglobulin secretion in alcoholic patients with and without cirrhosis

Cited by 13 publications

References 21 publications

Alcohol-associated bowel disease: new insights into pathogenesis

Alcohol-associated bowel disease: new insights into pathogenesis

Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease

Gut–liver axis: barriers and functional circuits

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