Jejunal infantile fibrosarcoma: An unusual cause of neonatal intestinal obstruction

Kotb, Mostafa; Aboelela, Ahmed; Eshiba, Ahmed; Sheta, Eman; Abdallah, Dina

doi:10.1111/cga.12433

Cited by 1 publication

(1 citation statement)

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“…IFS is a rare tumor that often presents as a single localized painless mass with rapid growth, most commonly found in the extremities and trunk and less commonly in the oral cavity, head and neck, colon, jejunum, periorbital, abdomen, and other sites ( 6 – 9 ). In this case, the mass of the newborn is located in the left lower limb, consistent with previous literature reports ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review

Wang¹,

Zhang²,

Wang³

et al. 2023

Front. Oncol.

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Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromosomal translocation resulting in ETV6-NTRK3 gene fusion, which provides the target for targeted therapy. Here, we report a case of IFS in a newborn with a mass in the left lower extremity confirmed by imaging, histopathological examination, tissue FISH testing, and high-throughput sequencing to detect gene rearrangement. Based on gene fusion targeted drug testing results, the patient was treated with standard doses of larotrectinib, resulting in significant mass shrinkage with no adverse effects, demonstrating the treatment effect of targeted therapy. This case provides a reference for using larotrectinib in newborns with IFS.

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Section: Discussionmentioning

confidence: 99%