Jerusalem artichoke inulin supplementation ameliorates hepatic lipid metabolism in type 2 diabetes mellitus mice by modulating the gut microbiota and fecal metabolome

Li, Jianpeng; Jia, Siqiang; Yuan, Chao; Yu, Bin; Zhang, Zheng; Zhao, Meng; Liu, Pengfei; Li, Xia; Cui, Bo

doi:10.1039/d2fo02051c

Cited by 18 publications

(6 citation statements)

References 68 publications

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“…The higher abundance of Prevotellaceae not only protects intestinal epithelial cells against oxidative stress, thereby, alleviating inflammatory symptoms in patients with inflammatory bowel diseases, but also beneficial for preventing obesity (103,104). Consistent with this study, Jerusalem artichoke inulin also enriched several genera of the Prevotelaceae family, and improved lipid metabolism in type 2 diabetes mice (105). This suggested that Prevotellaceae might be the key family for BI to exert its effect on lipid-lowering.…”

Section: Discussionsupporting

confidence: 84%

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

et al. 2023

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ObjectiveThe present study aimed to investigate the lipid-lowering effects and mechanisms of fenugreek gum (FG), hawthorn pectin (HP), and burdock inulin (BI) on high-fat diet (HFD)-induced hyperlipidemic rats.MethodsIn this study, high-fat diet (HFD) together with fat emulsion administration were used to establish hyperlipidemia model. The biochemical indices were assayed after administration of FG, HP, and BI. Their effects were evaluated by factor analysis. Alterations of gut microbiota and short chain fatty acids (SCFAs) in the cecal were assessed to illustrate the mechanism of lipid lowering.ResultsThe supplementation of FG, HP, and BI on HFD-fed rats decreased the levels of serum lipid and reduced the HFD-related liver and testicle damage. In the scatter plot of factor analysis, HP and BI were closer to normal fat diet (NFD) group in restoring the severity of hyperlipidemia, while FG and HP enhanced the excretion of cholesterol and bile acids (BAs). The levels of total SCFAs, especially butyric acid reduced by HFD were increased by HP. The ratio of Firmicutes to Bacteroidetes increased by HFD was reduced by HP and BI. FG, HP, and BI enriched intestinal probiotics, which were related to bile acid excretion or lipid-lowering.ConclusionsFG inhibited the absorption of cholesterol and enhanced the excretion of it, as well as increased the abundance of beneficial bacteria. While BI restored the imbalance of intestinal microbiota. HP enhanced the excretion of cholesterol and BAs, and restored the imbalance of intestinal microbiota. It was also utilized by intestinal microorganisms to yield SCFAs. This study suggested that FG, HP, and BI possessed the potential to be utilized as dietary supplements for obesity management.

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Section: Discussionsupporting

confidence: 84%

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

et al. 2023

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“…Consistent with these findings, our data revealed that in the HBW group, serum levels of specific PC species, namely PC (20:3/20:1) and PC (22:5/18:3), were significantly elevated and positively correlated with the abundance of Prevotellaceae_UCG-001. Interestingly, the work of Li et al [49] supports the notion that the enrichment of Prevotellaceae_UCG-001 in the intestines of mice, particularly those fed with Jerusalem artichoke and inulin, is closely associated with increased PC levels. Additionally, our study revealed that HBW goat kids exhibit elevated relative concentrations of adipic acid and 2-hydroxymyristic acid.…”

Section: Discussionmentioning

confidence: 86%

Exploring the Rumen Microbiota and Serum Metabolite Profile of Hainan Black Goats with Different Body Weights before Weaning

Zheng,

Wang,

Mao

et al. 2024

Animals

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The critical role of the rumen microbiota in the growth performance of livestock is recognized, yet its significance in determining the body weight of goat kids before weaning remains less understood. To bridge this gap, our study delved into the rumen microbiota, serum metabolome, rumen fermentation, and rumen development in goat kids with contrasting body weights before weaning. We selected 10 goat kids from a cohort of 100, categorized into low body weight (LBW, 5.56 ± 0.98 kg) and high body weight (HBW, 9.51 ± 1.01 kg) groups. The study involved sampling rumen contents, tissues, and serum from these animals. Our findings showed that the HBW goat kids showed significant enrichment of VFA-producing bacteria, particularly microbiota taxa within the Prevotellaceae genera (UCG-001, UCG-003, and UCG-004) and the Prevotella genus. This enrichment correlated with elevated acetate and butyrate levels, positively influencing rumen papillae development. Additionally, it was associated with elevated serum levels of glucose, total cholesterol, and triglycerides. The serum metabonomic analysis revealed marked differences in fatty acid metabolism between the LBW and HBW groups, particularly in encompassing oleic acid and both long-chain saturated and polyunsaturated fatty acids. Further correlational analysis underscored a significant positive association between Prevotellaceae_UCG-001 and specific lipids, such as phosphatidylcholine (PC) (22:5/18:3) and PC (20:3/20:1) (r > 0.60, p < 0.05). In summary, this study underscores the pivotal role of the rumen microbiota in goat kids’ weight and its correlation with specific serum metabolites. These insights could pave the way for innovative strategies aimed at improving animal body weight through targeted modulation of the rumen microbiota.

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“…However, a negative correlation between Blautia and the serum level of Ile was also found. Several studies showed that Dubosiella presented a decreased abundance in T2DM mice and was significantly negatively related to TG, HOMA‐IR, FBG, TC, and LDL‐c (Li et al, 2022; Yin et al, 2022). However, two conflicting reports showed that Dubosiella presented an increased abundance in T2DM mice and was positively correlated with the circulating level of total BCAAs, Val, and Ile (Bao et al, 2022; Zhang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

Zheng

et al. 2023

Phytotherapy Research

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Elevations in circling branched‐chain amino acids (BCAAs) levels associated with insulin resistance and type 2 diabetes mellitus (T2DM). Morus alba L. water extracts (MLE) show hypoglycemic function, but the precise mechanism remains obscure. This study is designed to investigate the association of the antidiabetes effect of MLE with the BCAAs co‐metabolism modulated by host and gut microbiota. Tissue‐specific expressions of BCAA‐catabolizing enzymes were detected by RT‐PCR and western blot, respectively. The components of the intestinal microflora were analyzed by high‐throughput 16S rRNA gene sequencing. The results showed that MLE administration improved blood glucose and insulin level, decreased inflammatory cytokines expression, and lowered serum and feces BCAAs levels. Furthermore, MLE reversed the abundance changes of the bacterial genera correlated with serum and feces BCAAs, such as Anaerovorax, Bilophila, Blautia, Colidextribacter, Dubosiella, Intestinimonas, Lachnoclostridium, Lachnospiraceae_NK4A136, Oscillibacter, and Roseburia. Functionality prediction indicated that MLE potentially inhibited bacterial BCAAs biosynthesis, and promoted the tissue‐specific expression of BCAAs catabolic enzyme. More importantly, MLE had obvious impacts on BCAA catabolism in germ‐free‐mimic T2DM mice. Those results indicated that MLE improving T2DM‐related biochemical abnormalities is associated with not only gut microbiota modification but also the tissue‐specific expression of BCAAs catabolic enzyme.

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Jerusalem artichoke inulin supplementation ameliorates hepatic lipid metabolism in type 2 diabetes mellitus mice by modulating the gut microbiota and fecal metabolome

Abstract: The main focus of this study was on the protection mechanism of Jerusalem artichoke inulin (DI) against type 2 diabetes mellitus (T2DM) associated with abnormal hepatic lipid metabolism and gut...

Cited by 18 publications

References 68 publications

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin

Exploring the Rumen Microbiota and Serum Metabolite Profile of Hainan Black Goats with Different Body Weights before Weaning

Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota‐host co‐metabolism of branched‐chain amino acid

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