The Ni-based desulfurization (De-S) sorbent selected by this study can efficiently removes the most refractory and intractable organic sulfur compounds from commercial ULSD (ultra low sulfur diesel) fuel to [S] < 1 ppmw through screening of the De-S materials, optimizations of operating conditions at micro-reactor, and design, fabrication and testing at a full-scale novel De-S reactor, which has the characteristics of no H 2 addition to desulfurizer required, recovering energy from hot De-S diesel stream to cold un-De-S diesel fed into the De-S bed, allowing easy serviceability including loading/reloading of De-S sorbent and meeting the need of the designed rate for 10 KW e FP (fuel processor)/FC (fuel cell) APU (accelerated power unit) system. As an alternative approach of pre-ATR (autothermal reforming) liquid-phase sulfur removal, a processing technology based on a combination of sulfur tolerant ATR catalyst with a following H 2 S trap is also developed. Catalyst formulation, substrate property, preheating & vaporization, mixing and distribution of liquid HC fuels, reactor design and controls play the equally important roles for the performance of sulfurtolerant ATR. SMSI (strong metal support interaction) is a key factor for sulfur-tolerant ATR catalyst.