Jewish Population in the United States, 2013

Sheskin, Ira M.; Dashefsky, Arnold

doi:10.1007/978-3-319-01658-0_5

Cited by 9 publications

(18 citation statements)

References 6 publications

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“…A by-product of this effort is that the aggregation of these local estimates yields an estimate of the total American Jewish population, an estimate that actually may be a bit too high as explained briefl y in Sect. 17.3 below and in more detail by Sheskin and Dashefsky ( 2006 ). The national estimate presented below, however, is in general agreement with the recent estimates of the Pew Research Center and the Steinhardt Social Research Institute at Brandeis University (see Sect.…”

Section: Population Estimation Methodologysupporting

confidence: 88%

“…There is no common agreement on what demographers term the "population at risk," on who is a Jew, and where the boundaries of the population lie. The 1971 National Jewish Population Survey methodologies all used different screening questions and unique categories for analysis and Pew's were different yet again. So comparisons across surveys and time are diffi cult.…”

Section: Markermentioning

confidence: 99%

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American Jewish Year Book 2014

Dashefsky¹,

Sheskin²

2015

American Jewish Year Book

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Section: Population Estimation Methodologysupporting

confidence: 88%

Section: Markermentioning

confidence: 99%

American Jewish Year Book 2014

Dashefsky¹,

Sheskin²

2015

American Jewish Year Book

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“…Similarly, in the FHS, the ancestries are predominantly Irish (15%) or other British (20%), Italian (19%), and other Western European (32%) [29]. There is also a sizeable Ashkenazi population in Framingham constituting perhaps 5% of the total population [35]. …”

Section: Discussionmentioning

confidence: 99%

“…The FHS cohorts have been genotyped using the Affymetrix 500K SNP array [29], and this data was used for the genetic analyses. The FHS cohorts are primarily white and contain a mix of different ethnic white subpopulations characteristic of the greater Boston metropolitan area, including substantial proportions of Northern/Western Europeans (Irish, English), Southern Europeans (Italians), and individuals of Ashkenazi ancestry [29, 35]. Here spouse-pairs were identified by having at least one offspring in the subsequent generation cohort.…”

Section: Methodsmentioning

confidence: 99%

Structured mating: Patterns and implications

et al. 2017

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Genetic similarity of spouses can reflect factors influencing mate choice, such as physical/behavioral characteristics, and patterns of social endogamy. Spouse correlations for both genetic ancestry and measured traits may impact genotype distributions (Hardy Weinberg and linkage equilibrium), and therefore genetic association studies. Here we evaluate white spouse-pairs from the Framingham Heart Study (FHS) original and offspring cohorts (N = 124 and 755, respectively) to explore spousal genetic similarity and its consequences. Two principal components (PCs) of the genome-wide association (GWA) data were identified, with the first (PC1) delineating clines of Northern/Western to Southern European ancestry and the second (PC2) delineating clines of Ashkenazi Jewish ancestry. In the original (older) cohort, there was a striking positive correlation between the spouses in PC1 (r = 0.73, P = 3x10-22) and also for PC2 (r = 0.80, P = 7x10-29). In the offspring cohort, the spouse correlations were lower but still highly significant for PC1 (r = 0.38, P = 7x10-28) and for PC2 (r = 0.45, P = 2x10-39). We observed significant Hardy-Weinberg disequilibrium for single nucleotide polymorphisms (SNPs) loading heavily on PC1 and PC2 across 3 generations, and also significant linkage disequilibrium between unlinked SNPs; both decreased with time, consistent with reduced ancestral endogamy over generations and congruent with theoretical calculations. Ignoring ancestry, estimates of spouse kinship have a mean significantly greater than 0, and more so in the earlier generations. Adjusting kinship estimates for genetic ancestry through the use of PCs led to a mean spouse kinship not different from 0, demonstrating that spouse genetic similarity could be fully attributed to ancestral assortative mating. These findings also have significance for studies of heritability that are based on distantly related individuals (kinship less than 0.05), as we also demonstrate the poor correlation of kinship estimates in that range when ancestry is or is not taken into account.

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“…However, the observed disease prevalence among North American Ashkenazi Jews is substantially lower than predicted. In South Florida, home to an estimated 500,000 Ashkenazi Jews [9], only approximately 100 Ashkenazi Jews with GD1 have been identified over a 20 year period (NJW, personal observation). This lower than expected prevalence is comparable to other US metropolitan areas with large Ashkenazi Jewish populations [10,11].…”

Section: Introductionmentioning

confidence: 99%

Patients with type 1 Gaucher disease in South Florida, USA: demographics, genotypes, disease severity and treatment outcomes

Orenstein

Barbouth

Bodamer

et al. 2014

Orphanet J Rare Dis

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BackgroundGaucher disease, an autosomal recessive condition due to deficiency of lysosomal glucocerebrosidase, is a multisystemic disease, with variable age of onset, severity and progression. It is classified into subtypes delineated by the absence (type 1) or presence (type 2 and 3) of primary nervous system involvement.The ethnically diverse, largely immigrant population in South Florida has a spectrum of Gaucher disease phenotypes, creating a challenge for optimization of disease management and an opportunity to explore treatment patterns.MethodsNinety-three records from patients with Gaucher type I in South Florida were retrieved from the International Collaborative Gaucher Group (ICGG) Registry. Individual genotypes were correlated with severity scores and success at achieving published therapeutic goals for haemoglobin concentration, platelet count, spleen volume, liver volume and amelioration of bone pain and bone crises.ResultsThe majority of patients were diagnosed during the fifth decade of life. Almost two-thirds were homozygous for the N370S mutation, reflecting the large Ashkenazi Jewish population in South Florida. The majority received imiglucerase (62.8%) at various intervals. 24.5% of patients underwent splenectomy before starting enzyme replacement therapy. After a median 12 treatment years, South Florida patients matched or exceeded the ICCG 4 year therapeutic goal achievement for platelet count (85.4% vs. 79.6% success), spleen volume (93.3% vs. 78.0% success), liver volume (93.4% vs. 90.6% success), and bone crises (100% vs. 99% success). Nevertheless, fewer patients with intact spleens had sustained achievement of all 6 therapeutic goals (30.4% versus 41.4%) and only 40% of the splenectomy patients sustained achievement of 5/5 possible goals. 54.7% of the intact spleen patients continued to have bone pain vs. 29.8% in ICCG. Significantly, only 37% of the ICGG patient cohort had bone pain prior to initiation of treatment compared to 73.4% of the South Florida patients (moderate or severe pain in 59.6%).ConclusionsDemographic characteristics are a significant determinant of the differences in response to treatment observed in South Florida Gaucher patients compared to those described in the international population enrolled in the ICGG Gaucher Registry. Individual genotypes and ethnic background are important considerations for optimizing patient care for Gaucher disease.

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Jewish Population in the United States, 2013

Cited by 9 publications

References 6 publications

American Jewish Year Book 2014

American Jewish Year Book 2014

Structured mating: Patterns and implications

Patients with type 1 Gaucher disease in South Florida, USA: demographics, genotypes, disease severity and treatment outcomes

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