Jian-Yan-Ling capsules ameliorate cognitive impairment in mice with D-galactose-induced senescence and inhibit the oxidation-induced apoptosis of HT22 hippocampal cells by regulating the Nrf2-HO1 signaling pathway

Lou, Qianyin; Meng, Xue-Er; Wei, Chongqi; Tong, Jiaxiang; Chen, Yang; Li, Mengting; Wang, Qingqing; Guo, Shouwu; Duan, Jin‐Ao; Shang, Erxin; Zhu, Yue

doi:10.1016/j.jep.2023.116356

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…The results demonstrated a signi cant increase in hippocampus total iron in the AD model group, which may be attributed to the deposition of beta-amyloid(Viktorinova & Dur nova, 2021). Moreover, excessive iron accumulation due to long-term exposure to D-galactose increases oxidative stress, and reduces antioxidant activities that subsequently accelerate degenerative changes in the brain, as with normal aging (Lou et al, 2023). However, co-treatment with spermidine and/or cipro oxacin normalized the iron levels in the AD group, indicating their iron-chelating effects and protection against oxidative stressinduced brain degeneration.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of spermidine and ciprofloxacin against Alzheimer disease in male rat via ferroptosis modulation

Youssef,

Mohamed,

Bakry

et al. 2023

Preprint

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Alzheimer's disease (AD) is a prevalent form of neurodegenerative disease with a complex pathophysiology that remains not fully understood, and the exact mechanism of neurodegeneration is uncertain. Ferroptosis, a programmed cell death mechanism mediated by iron, has been linked to the progression of degenerative diseases observed in clinical AD models. In this study, we aimed to explore the synergistic effects of spermidine and/or ciprofloxacin in combating Alzheimer's disease (AD). We investigated AD-related biomarkers, including neurotoxic Aβ, arginaseI, and serotonin.Spermidine demonstrated an anti-ferroptotic effect in the AD model, evident from the modulation of ferroptosis parameters such as hippocampus iron levels, reduced protein expression of transferrin receptor 1 (TRF1), and arachidonate 15-lipoxygenase (ALOX15). Additionally, the administration of spermidine led to a significant increase in protein expression of phosphorylated nuclear factor erythroid 2-related factor 2 (p-Nrf2) and upregulation of Cystine/glutamate transporter (SLC7A11) gene expression. Moreover, spermidine notably decreased p53 protein levels, acrolein, and gene expression of spermidine/spermine N1-acetyltransferase 1 (SAT1). The histopathological examination of hippocampus tissue corroborated these results obtained from molecular biochemical inspection. Overall, our findings suggest that spermidine and/or ciprofloxacin may offer potential benefits against Alzheimer's disease (AD) by modulating ferroptosis. Furthermore, spermidine enhanced the antioxidant efficacy of ciprofloxacin and reduced its toxic effects by increasing antioxidant enzymes, thereby enhancing its potency against oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Synergistic effect of spermidine and ciprofloxacin against Alzheimer disease in male rat via ferroptosis modulation

Youssef,

Mohamed,

Bakry

et al. 2023

Preprint

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“…Upregulation of NRF2 has been suggested as a mechanism for reduced cellular senescence in models of diseases such as osteoporosis [ 180 ], age-related macular degeneration [ 181 ], age-related cognitive decline [ 182 ] and renal fibrosis [ 183 ]. Recently, Liu et al described how NRF2 is activated during DOX-induced senescence in two human cancer cell lines and in vivo by an accumulation of the oncogene iASPP (Inhibitor of Apoptosis Stimulating Protein of P53), which binds and inhibits KEAP1 [ 184 , 185 ].…”

Section: Drug-induced Cardiotoxicity and The Role Of Nrf2mentioning

confidence: 99%

Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling

Roberts

Rainbow

Sharma

2023

IJMS

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Cardiovascular toxicity and diseases are phenomena that have a vastly detrimental impact on morbidity and mortality. The pathophysiology driving the development of these conditions is multifactorial but commonly includes the perturbance of reactive oxygen species (ROS) signalling, iron homeostasis and mitochondrial bioenergetics. The transcription factor nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2), a master regulator of cytoprotective responses, drives the expression of genes that provide resistance to oxidative, electrophilic and xenobiotic stresses. Recent research has suggested that stimulation of the NRF2 signalling pathway can alleviate cardiotoxicity and hallmarks of cardiovascular disease progression. However, dysregulation of NRF2 dynamic responses can be severely impacted by ageing processes and off-target toxicity from clinical medicines including anthracycline chemotherapeutics, rendering cells of the cardiovascular system susceptible to toxicity and subsequent tissue dysfunction. This review addresses the current understanding of NRF2 mechanisms under homeostatic and cardiovascular pathophysiological conditions within the context of wider implications for this diverse transcription factor.

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Flavonoids from Liriodendron chinense Leaves Alleviate Oxidative Activity in Vitro and D-galactose-induced Brain Injury via AMPK/SIRT1 Pathway in Vivo

Li,

Zeng,

Feng

et al. 2024

Industrial Crops and Products

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Jian-Yan-Ling capsules ameliorate cognitive impairment in mice with D-galactose-induced senescence and inhibit the oxidation-induced apoptosis of HT22 hippocampal cells by regulating the Nrf2-HO1 signaling pathway

Cited by 6 publications

References 41 publications

Synergistic effect of spermidine and ciprofloxacin against Alzheimer disease in male rat via ferroptosis modulation

Synergistic effect of spermidine and ciprofloxacin against Alzheimer disease in male rat via ferroptosis modulation

Mitigation of Cardiovascular Disease and Toxicity through NRF2 Signalling

Flavonoids from Liriodendron chinense Leaves Alleviate Oxidative Activity in Vitro and D-galactose-induced Brain Injury via AMPK/SIRT1 Pathway in Vivo

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