Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Li, Lin; Li, Yanlin; Zhou, Yunfeng; Zhang, Ge; Wang, Lili; Li, Zhiqiang; Guo, Yujie; Jin, Long; Ren, Ye; Liu, Jianxun; Xu, Yuanfu

doi:10.1007/s11655-016-2595-x

Cited by 10 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats in the diabetic group and diabetic+SDMM capsule group were injected with a single intraperitoneal injection of STZ at a dose of 50 mg/kg. 19 Blood glucose levels (Mm) were measured 3d and 7d after dosing, and rats with blood glucose levels higher than 16.7 mmol/L were selected for subsequent experiments and randomly divided into a diabetic group and diabetic+SDMM capsule group. Rats in the normal group received an equal amount of citrate buffer.…”

Section: Methodsmentioning

confidence: 99%

Effect of Shuangdan Mingmu Capsule on Diabetic Retinopathy in Rats via Regulation of miRNAs

Li¹,

Yang²,

Yan³

et al. 2022

DMSO

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Effect of Shuangdan Mingmu Capsule on Diabetic Retinopathy in Rats via Regulation of miRNAs

Li¹,

Yang²,

Yan³

et al. 2022

DMSO

View full text Add to dashboard Cite

“…The STZ-induced diabetic rats displays retinal changes similar to those observed in the early stages of human DR. Cellular and molecular changes in STZ-induced DR are involved in breakdown of the BRB [162], decreases in pericytes and endothelial cells [163], and thickening of the basement membrane [70]. Oxidative stress is a key regulator of diabetic complications [164, 165].…”

Section: Neuroprotective Mechanisms In Dr Induced By Streptozotocimentioning

confidence: 99%

Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration

Liu

Wang

2019

Journal of Ophthalmology

View full text Add to dashboard Cite

Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. Stimulating intrinsic neuronal regeneration is a potential approach to therapy in retinal degenerative diseases. In contrast to stem cells, as embryonic/pluripotent stem cell-derived retinal progenitor cell or mesenchymal stem cells, Müller glia provided an endogenous cellular source for regenerative therapy in the retina. Müller glia are a major component of the retina and considerable evidence suggested these cells can be induced to produce the lost neurons in several species. Understanding the specific characteristic of Müller glia to generate lost neurons will inspire an attractive and alternative therapeutic strategy for treating visual impairment with regenerative research. This review briefly provides the different signal transduction mechanisms which are underlying Müller cell-mediated neuroprotection and neuron regeneration and discusses recent advances about regeneration from Müller glia-derived progenitors.

show abstract

“…Induction of DR by STZ has been observed in multiple models including mice, rabbits, pigs, rats, dogs, zebrafish, and monkeys [31,[63][64][65][66][67][68][69][70]. STZ is now generally preferred over alloxan, as it is more effective in recapitulating the diabetic disease state, though both drugs are still commonly used [41].…”

Section: Streptozotocinmentioning

confidence: 99%

“…The onset of retinal lesions differs between rat strains, but several observed phenotypes include BRB breakdown 2 weeks after diabetes onset [74,75], ONL thinning beginning the in the fourth week following induction [74], increased acellular capillaries, decreased numbers of both pericytes and endothelial cells after 8 weeks [67], and basement membrane thickening after 1 year [68]. STZinduced DR rat models are typically studied for up to 20 weeks [75].…”

Section: Streptozotocinmentioning

confidence: 99%

Animal Models of Diabetic Retinopathy

Chen

Stitt

2015

Animal Models of Ophthalmic Diseases

View full text Add to dashboard Cite

Purpose of Review Diabetic retinopathy (DR) is one of the most common complications associated with chronic hyperglycemia seen in patients with diabetes mellitus. While many facets of DR are still not fully understood, animal studies have contributed significantly to understanding the etiology and progression of human DR. This review provides a comprehensive discussion of the induced and genetic DR models in different species and the advantages and disadvantages of each model. Recent FindingsRodents are the most commonly used models, though dogs develop the most similar morphological retinal lesions as those seen in humans, and pigs and zebrafish have similar vasculature and retinal structures to humans. Nonhuman primates can also develop diabetes mellitus spontaneously or have focal lesions induced to simulate retinal neovascular disease observed in individuals with DR. Summary DR results in vascular changes and dysfunction of the neural, glial, and pancreatic β cells. Currently, no model completely recapitulates the full pathophysiology of neuronal and vascular changes that occur at each stage of diabetic retinopathy; however, each model recapitulates many of the disease phenotypes.

show abstract

Jiangtang Xiaozhi Recipe (降糖消脂方) prevents diabetic retinopathy in streptozotocin-induced diabetic rats

Abstract: JXR have protective effect of diabetic retinopathy and its mechanism may be associated with the obvious hypoglycemic and antioxidant effect.

Cited by 10 publications

References 33 publications

Effect of Shuangdan Mingmu Capsule on Diabetic Retinopathy in Rats via Regulation of miRNAs

Effect of Shuangdan Mingmu Capsule on Diabetic Retinopathy in Rats via Regulation of miRNAs

Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration

Animal Models of Diabetic Retinopathy

Contact Info

Product

Resources

About